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Clemastine Fumarate (14976-57-9) C25H30ClNO5

  • Chemical Name: Clemastine fumarate
  • CAS No.: 14976-57-9
  • MF: C25H30ClNO5
  • MW: 459.96
  • Specification: USP|EP|BP
  • Purity:98% or As customer requested
  • Color: white to beige
  • Solubility:DMSO: soluble5mg/mL (clear solution; warmed)
  • Test method: HPLC
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Clemastine fumarate is the fumaric acid salt of clemastine. An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions. It has a role as a H1-receptor antagonist, an anti-allergic agent, a muscarinic antagonist and an antipruritic drug. It contains a clemastine. (Source: ChEBI)

Clemastine Fumarate Basic information       
Product Name: Clemastine fumarate
Synonyms: CLEMASTINE FUMARATE; CLEMASTINE FUMARATE SALT; (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrro; (+)-2-(2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrroli; (+)-lfumarate(1:1); 1-methyl-2-(2-(methyl-p-chlorodiphenylmethyloxy)ethyl)pyrrolidine; (2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE; 2-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine
CAS: 14976-57-9
MF: C25H30ClNO5
MW: 459.96
EINECS: 239-055-2
Product Categories: antianaphylaxis; TAVIST; Histaminergics; Antagonists; Neurotransmitters; Aromatics; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File: 14976-57-9.mol

Tavist Chemical Structure

Clemastine fumarate            

Tavegil Chemical Properties
Melting point  158-162°C
alpha  D21 +16.9° (methanol)
Boiling point  154°C (rough estimate)
density  1.0247 (rough estimate)
refractive index  1.5790 (estimate)
storage temp.  Store at RT
solubility  DMSO: soluble5mg/mL (clear solution; warmed)
form  powder
color  white to beige
optical activity [α]/D +15 to +25°, c = 1 in methanol
InChIKey PMGQWSIVQFOFOQ-YKVZVUFRSA-N
CAS DataBase Reference 14976-57-9(CAS DataBase Reference)

Agasten Usage And Synthesis


Chemical Properties White Solid

Uses

H1 Histamine receptor antagonist. Antihistaminic.
anti-inflammatory
Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM). It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling. Clemastine fumarate has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.
Definition ChEBI: The fumaric acid salt of clemastine. An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin condi ions.
Manufacturing Process 9.9 g of α-methyl-p-chlorobenzhydrol are added to a suspension of 2.3 g of powdered sodamide in 30 cc of benzene. Subsequently 7.4 g of Nmethylpyrrolidyl-(2)-ethyl chloride are added and the solution is heated to the boil at reflux for 20 hours. Then shaking is first effected with water and then 4 times each time with 25 cc of 2 N hydrochloric acid. The acid extracts are made alkaline with potassium hydroxide solution while cooling strongly, and the precipitated oil is extracted with ether. After drying of the ethereal solution over potassium carbonate, the solvent is evaporated and the residue is fractionally distilled in a high vacuum, whereby N-methyl-2-[2'-(α-methyl-pchlorobenzhydryloxy)-ethyl]-pyrrolidine boils over at 154°C/0.02 mm Hg. The base is converted to the fumarate by reaction with fumaric acid.
Therapeutic Function Antihistaminic

MSDS: MSDS available


COA: COA can be available if you send us inquiry.


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