Cefuroxime Sodium

Description

Cefuroxime Sodium is the sodium salt form of cefuroxime and a semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic with bactericidal activity.

Cefuroxime sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. Lack of cross-linking results in a reduction of cell wall stability and leads to cell lysis.

Basic information

Product Name:	Cefuroxime sodium
Synonyms:	CEFUROXIME NA; CEFUROXIME SODIUM; CEFUROXIME SODIUM SALT
CAS:	56238-63-2
MF:	C16H15N4O8S.Na
MW:	446.37
EINECS:	260-073-1
Product Categories:	Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur&Selenium Compounds; Pharmaceutical intermediate

Chemical Structure

Cefuroxime sodium

Chemical Properties

Melting point	240-245°C(dec)
alpha	D20 +60° (c = 0.91 in water)
storage temp.	Inert atmosphere,2-8°C
solubility	Freely soluble in water, very slightly soluble in ethanol (96 per cent).
pka	pKa (water): 2.5; (DMF): 5.1(at 25℃)
form	neat
Water Solubility	Freely soluble in water

Usage And Synthesis

Cefuroxime sodium is an off-white to white amorphous powder. Cefuroxime sodium is an injectable second generation, semisynthetic, broad spectrum cephalosporin antibiotic with excellent activity in vitro, enhanced stability to many enterobacterial β-lactamases and favorable pharmacokinetic properties.