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Fingolimod Hydrochloride(162359-56-0)C19H34ClNO2

  • Chemical Name: Fingolimod hydrochloride
  • CAS No.:162359-56-0
  • MF: C19H34ClNO2
  • MW: 343.93
  • Purity: ≥98% or according to customer requested
  • Color: white to beige
  • Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;APIs; Inhibitors;
  • Test method: HPLC
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What is Fingolimod Hydrochloride?

Fingolimod Hydrochloride is the hydrochloride salt form of fingolimod, an orally available derivate of myriocin and sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) modulator, with potential anti-inflammatory and immunomodulating activities. Upon oral administration, fingolimod, as a structural analogue of sphingosine, selectively targets and binds to S1PR1 on lymphocytes and causes transient receptor activation followed by S1PR1 internalization and degradation. This results in the sequestration of lymphocytes in lymph nodes. By preventing egress of lymphocytes. fingolimod reduces both the amount of circulating peripheral lymphocytes and the infiltration of lymphocytes into target tissues. This prevents a lymphocyte-mediated immune response and may reduce inflammation. S1PR1, a G-protein coupled receptor, plays a key role in lymphocyte migration from lymphoid tissues. Fingolimod also shifts macrophages to an anti-inflammatory M2 phenotype, and modulates their proliferation, morphology, and cytokine release via inhibition of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7). (Source: NCI Thesaurus (NCIt))

Introduction 
Product Name: Fingolimod hydrochloride
Synonyms: Fingolimod (FTY720) hydrochloride; Finlimod hydrochloride; fingolimod hydrochloride;FTY720;2-AMINO-2-[2-(4-OCTYLPHENYL)ETHYL]-1,3-PROPANEDIOL, HYDROCHLORIDE;2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride;Fingolimod HCl; Fingolimod-d4 Hydrochloride; fingolimod
CAS: 162359-56-0
MF: C19H34ClNO2
MW: 343.93
EINECS: 680-631-1
Product Categories: Pharmaceuticals; Intermediates & Fine Chemicals; API; Inhibitors
Chemical Structure

Fingolimod hydrochloride            

Chemical Properties     

Melting point: 102-107°C

storage temp. : -20°C

solubility water: soluble10mg/mL, clear

form:  powder

color:  white to beige

Fingolimod hydrochloride Uses And Synthesis

Fingolimod hydrochloride is the hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod). It has a role as a sphingosine-1-phosphate receptor agonist, an immunosuppressive agent and a prodrug. It is a hydrochloride and an organic salt. It contains a fingolimod(1+).



Uses
A derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibitin
Oral medicine for the treatment of multiple sclerosis

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

Email us at: info@maxmedchem.com for more details.

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