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Isonicotinic Acid

  • Chemical Name: Isonicotinic Acid
  • CAS No.: 55-22-1
  • MF: C6H5NO2
  • MW: 123.11
  • Specification: USP|EP|BP
  • Purity: >98% or As customer requested
  • Color: white to light yellow crystal powder
  • Solubility:6g/l
  • Product Categories: Nitrogen cyclic compounds;API’s; Chemical Synthesis;Pyridine;Pyridines
  • Test method: HPLC


Isonicotinic acid is a pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring. It has a role as a human metabolite and an algal metabolite. It is a conjugate acid of an isonicotinate. 

Basic information 

Product Name: Isonicotinic acid
Synonyms: 4-PYRIDINECARBOXYLIC ACID FOR SYNTHESIS;Isonicotinic aci;66 kDa neurofilament protein;ANTI-INA (ALPHA INTERNEXIN) (CENTER) antibody produced in rabbit;NEF5;Neurofilament 5;Pyridine-4-carboxylic acid, 4-Carboxypyridine;Isonicotinic acid, CP,98%
CAS: 55-22-1
MW: 123.11
EINECS: 200-228-2
Product Categories: Nitrogen cyclic compounds; API’s; Chemical Synthesis; Pyridine; API intermediates
Chemical Structure

Isonicotinic acid            

Chemical Properties


Melting point  ≥300 °C (lit.)
Boiling point  260 °C (15 mmHg)
density  1,47g/cm
refractive index  1.5423 (estimate)
Fp  260°C/15mm
storage temp.  no restrictions.
solubility  6g/l
pka 4.96(at 25℃)
form  powder
color  yellow to tan
PH 3-4 (6g/l, H2O, 20℃)(saturated solution)
Water Solubility  5.2 g/L (20 ºC)
Merck  14,5187
BRN  109599
Usage And Synthesis   

Chemical Properties white to light yellow crystal powder
Uses Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. The chronic toxicity of isonicotinic acid is slightly higher than that of isonicotinic acid hydrazide ( INH ) .
Isonicotinic acid considered to be inactive isomer of nicotinic acid. Isonicotinic acid is a metabolite of pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid) a front-line weapon in the battle against tuberculosis. Isonicotinic acid and its derivatives are used in manufacturing pharmaceuticals and agrochemicals.
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Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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