Kojic Acid

Description

What is Kojic acid?

Kojic acid is a pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4.

kojic acid for skin has been isolated from the fungus Aspergillus oryzae. It has a role as a NF-kappaB inhibitor, an Aspergillus metabolite, a skin lightening agent, an EC 1.10.3.1 (catechol oxidase) inhibitor, an EC 1.10.3.2 (laccase) inhibitor, an EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor and an EC 1.4.3.3 (D-amino-acid oxidase) inhibitor. It is an enol, a primary alcohol and a member of 4-pyranones. It derives from a hydride of a 4H-pyran.

Basic information

Product Name:	Kojic acid
Synonyms:	4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-; 4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl)-; 5-hydroxy-2-(hydroxymethyl)-4h-pyran-4-on; kojic; Pyran-4-one, 5-hydroxy-2-(hydroxymethyl); 2-HYDROXYMETHYL-5-HYDROXY-4-PYRONE; 5-Hydroxy-2-(hydroxymethyl)-γ-pyrone; Kojic acid
CAS:	501-30-4
MF:	C6H6O4
MW:	142.11
EINECS:	207-922-4
Product Categories:	Pyridines; Cosmetics; Herb extract; inhibitor; FINE Chemical & INTERMEDIATES; Heterocycles

Chemical Structure

Kojic acid

Chemical Properties

Melting point	152-155 °C (lit.)
Boiling point	179.65°C (rough estimate)
density	1.1712 (rough estimate)
refractive index	1.4434 (estimate)
storage temp.	Store below +30°C.
pka	7.9(at 25℃)
form	Crystalline Powder
color	White to beige-brown
Water Solubility	SOLUBLE
λmax	269nm(CHCl3)(lit.)
Merck	14,5317
BRN	120895
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.

Usage And Synthesis

Organic acids

Kojic acid is mainly used for skin whitening products, anti-aging products, sunscreen products, whitening facial cleanser and cosmetics.
Kojic acid has certain antibacterial activity. Gram negative bacteria of kojic acid sodium of sensitive degree is greater than gram positive bacteria, while most other contrary in the antimicrobial substances. Inhibitory effect of kojic acid for skin is far below other antibacterial substances and its antibacterial activity is bacteriostatic rather than sterilization. Kojic acid on yeast, virus and phage is invalid.

Physicochemical properties

Kojic acid crystal is prism shape, acicular, colorless. Kojic acid is soluble in water, alcohol, acetone, slightly soluble in ether, ethyl acetate, chloroform and pyridine, insoluble in most other solvent.

Can Kojic acid Used as Food Additive?

Kojic acid may be developed as a new food additive. As a food preservative sorbic acid is more than the performance of the ideal.

Kojic acid can be used for fresh vegetables, fruits, fresh seafood, such as the cut apple, bananas, potatoes, mushrooms in 0.1% kojic acid solution leaching for 1 hour, can effectively prevent browning.

As mentioned above, kojic acid of antibacterial, antisepsis, fresh-keeping, color protection hair color, antioxidant effect in a body is a potential and the superior performance of food additives.

Besides the above functions, kojic acid can be used for whitening cosmetics and food.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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