Chemical Name: L-Proline
CAS No.: 147-85-3
Purity: 99% or according to customer requirements
Product Categories: Amino Acids;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Food & Feed ADDITIVES;
Test method: HPLC



What is L-proline?

Humans and other animals are able to biosynthesize the l-proline, primarily from the non-essential amino acid L-glutamic acid, so it is considered non-essential. Proline is surprising in that it is heterocyclic, and in this way is the main regular amino corrosive that contains an optional amine bunch. In nature, only the L-enantiomer can be found.

Proline is also unusual because it was made before natural sources were isolated from it. D,L-racemate was made from N-methylproline in 1900 by German chemist Richard M. Willstätter, who won the Nobel Prize in Chemistry. Another German Nobel laureate, Emil Fischer, isolated the L-form from hydrolyzed casein and egg albumen the following year.

Biosynthesizing proteins makes use of proline, as well as all naturally occurring amino acids. L proline amino acid proteins have significantly distinct secondary structures from those of open-chain proteins due to its rigid five-membered ring.

Basic information

Product Name: L-Proline
Synonyms: L-Proline; L-2-Pyrrolidinecarboxylic acid; L-PROLINE, NATURAL; L-PROLINE, SYNTHETIC;L-(-)-PROLINE ((S)-(-)-PROLINE); L-PROLINE  99%; Prolinum; Prolina; (S)-Pyrrolidine-2-carboxylic acid
CAS: 147-85-3
MW: 115.13
EINECS: 205-702-2
Product Categories: Amino Acids;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Food & Feed ADDITIVES;
Chemical Structure


Chemical Properties  

Melting point  228 °C (dec.) (lit.)
alpha  -85.5 º (c=4, H2O)
Boiling point  215.41°C (rough estimate)
density  1.35
refractive index  -85 ° (C=4, H2O)
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
pka 1.95, 10.64(at 25℃)
form  powder
color  White
PH 6.0-7.0 (25℃, 1M in H2O)
optical activity [α]20/D 85.0±1.0°, c = 5% in H2O
Water Solubility  soluble
λmax λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
Sensitive  Hygroscopic
JECFA Number 1425
Merck  14,7780
BRN  80810
Stability: Stable. Incompatible with strong oxidizing agents.
Usage And Synthesis

Chemical Properties White crystalline powder
L-Proline, an amino acid, is odorless or has a slight, characteristic odor with a slightly sweet taste.
Occurrence Reported found as a component in many proteins; also widely occurring as the free acid in natural products. A major constituent of collagen, the main fibrous protein found in bone, cartilage and other connective tissue.
Uses amino acid, nutrient

L-proline Benefits:

Maintains Skin Health and Heals Wounds

Skin and connective tissue are made of collagen. Collagen is composed primarily of proline. Because the body wouldn’t be able to rebuild skin after an injury, wounds wouldn’t heal without l-proline—or, more accurately, without collagen. Likewise, your skin would hang since there’d not be anything to hold it set up (2). Connective tissue associates things together. Without it, everything falls apart. Consuming sufficient amounts of proline, hydroxyproline, and glycine, which are necessary for the production of collagen, aids in maintaining firm, healthy, and youthful-looking skin.

Strengthens the Gut Lining

Proline may aid in the treatment of leaky gut syndrome by supporting digestive function. When the gut lining develops tiny holes that allow pathogens to enter, this condition is known as leaky gut. Inflammation is sparked as a result. In order to rebuild any damaged intestinal cells and preserve the lining, amino acids like proline are required. In addition, proline improves immune function and reduces inflammation in the digestive system. Due to its high proline content, taking bone broth on a regular basis is a common treatment for leaky gut.

Reduces the Risk of Heart Disease

Heart disease is still the Most Common Cause of Death in the United States. Heart attacks and strokes are caused by blockage caused by fat accumulations in the artery walls. This keeps the blood from moving through. In any case, proline helps discharge a portion of this stuck fat, helping eliminate the blockage. This sends it back into the circulation system for use somewhere else. The risk of having a heart attack may be decreased by proline (4).

Reduces Inflammation and Aids in Stress Management

Proline amino acids promotes a healthy immune system by reducing inflammation. It also helps start a chain reaction of genes and anti-inflammatory compounds that help the body recover from stress in the environment. We are able to better deal with stress because proline helps produce energy in a more effective manner. Additionally, it aids in liver detoxification and repairs oxidative stress-damaged DNA. The immune system becomes stronger and inflammation decreases as a result of these functions. This makes you feel your best and lowers your risk of disease as a whole.

Strengthens Joints and Other Connective Tissue

Because l proline amino acid is a component of collagen, it is necessary for the repair of all kinds of connective tissue. Your bones are held in place by connective tissue, which also acts as a shock absorber. Ask anyone whose knee lacks connective tissue how painful life is without it! No thanks for bones grinding against each other!

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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