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  • Chemical Name: SAM-e
  • CAS No.: 29908-03-0
  • MF: C15H24N6O5S
  • MW: 400.45
  • Purity: ≥98% or according to customer requested
  • Color: off white
  • Product Categories: Pharmaceutical raw materials;APIs;Nutritional Supplements;API;Biochemical Engineering
  • Test method: HPLC
What is SAM-e?   

S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body. SAMe is sold in the United States as a dietary supplement.

SAMe was discovered in the early 1950s. It’s made in the body from methionine, an amino acid found in foods. It has been found to regulate key functions in living cells.

Abnormal levels of SAMe in the body have been reported in liver diseases and depression. This prompted researchers to investigate whether SAMe might be helpful in treating these conditions. The idea that SAMe might be helpful for osteoarthritis came from studies of SAMe for depression. Some of the participants in the depression studies who also had osteoarthritis said their joint symptoms improved when they took SAMe.

Product Name: S-Adenosyl-L-methionine
Synonyms: ADEMETIONINE; S-ADENOSYL-L-METHIONINE; SAM-E; adenosylmethionine; methioninyladenylate; p-Toluenesulfonate salt; ADEMETHIOINEDISULFATETOSYLATE; S-adenosyl methionine; S-adenosylmethionine; SAMe
CAS: 29908-03-0
MF: C15H24N6O5S
MW: 400.45
EINECS: 249-946-8
Product Categories: Nutritional Supplements; API
Chemical Structure


Chemical Properties  
storage temp. Inert atmosphere,Store in freezer, under -20°C
Sam-e benefits           

SAMe has been investigated most extensively for depression, osteoarthritis, and liver diseases. For all three conditions, research has not conclusively shown that SAMe is helpful.

Sam-e for depression

Overall, the evidence that oral SAMe may be helpful for depression is not conclusive.

At least 40 studies in people have evaluated SAMe for depression, and many of them showed evidence of beneficial effects. However, most of these trials lasted only a few weeks, included a small number of participants, and were not of the highest scientific quality. Also, some studies used injected SAMe rather than an oral form (taken by mouth).

Sam-e for Osteoarthritis

The results of research on SAMe for osteoarthritis are mixed.

Studies in people have compared oral SAMe with nonsteroidal anti-inflammatory drugs (NSAIDs; medicines used to relieve osteoarthritis pain) or placebos (inactive substances) in patients with osteoarthritis of the knee or hip.

Sam-e for Liver

There’s some evidence linking decreased levels of SAMe in the body with the development of liver diseases, and animal studies have suggested that SAMe may be of value for liver problems. 

Where to buy pharma grade SAMe? For us:

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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