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  • CAS No.: 6024-85-7
  • MF: C21H26ClNO4
  • MW:391.89
  • Specification: USP|EP|BP
  • Purity:98% or as customer requested
  • Chemical Properties:White Powder
  • CategorAies: API; Pharmaceuticals
  • Test method: HPLC


What is Tetrahydropalmatine?

Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.



Synonyms: (D,L)-TETRAHYDROPALMATINE HYDROCHLORIDE; TETRAHYDROPALMATINE HYDROCHLORIDE; SALOR-INT L202088-1EA; 2,3,9,10-tetramethoxy-,hydrochloride,(+-)-berbin; Tetrahydropalmatine Sulfate 6024-85-7; tetrahydro-,hydrochloride,(+-)-palmatin; Tetrahydropalmatine, HCl; corydalis B
CAS: 6024-85-7
MF: C21H26ClNO4
MW: 391.89
Product Categories: Natural Plant Extract; Inhibitors
Mol File: 6024-85-7.mol

Tetrahydropalmatine HCl Chemical Structure


Corydalis B Chemical Properties

Melting point  222-223 °C (decomp)
CAS DataBase Reference 6024-85-7(CAS DataBase Reference)

Tetrahydropalmatine Benefits:

Tetrahydropalmatine has been exhibited to have pain relieving impacts and might be helpful in the treatment of coronary illness and liver damage. It is a blocker of voltage-enacted L-type calcium channel dynamic potassium channels.[citation needed] It is a strong muscle relaxant.[citation needed] It has additionally shown possible in the treatment of chronic drug use to both cocaine and sedatives, and starter human examinations have shown promising results.

The pharmacological profile of tetrahydropalmatine incorporates threat of dopamine D1, and D2 receptors as well as activities at dopamine D3, alpha adrenergic and serotonin receptors. The Ki values for l-THP at D1 and D2 dopamine receptors are roughly 124 nM (D1) and 388 nM (D2). 

Notwithstanding the enmity of post-synaptic dopamine receptors, the bar of pre-synaptic autoreceptors by l-THP brings about expanded dopamine delivery, and it has been recommended that lower partiality of l-THP for D2 receptors might give some level of autoreceptor selectivity. Alongside dopamine receptors, l-THP has been accounted for to connect with various other receptor types, including alpha-1 adrenergic receptors, at which it capabilities as a main bad guy, and GABA-A receptors, through sure allosteric tweak. Moreover, tetrahydropalmatine shows huge restricting to 5-HT1A and alpha-2 adrenergic receptors. On account of 5-HT1A receptors, tetrahydropalmatine ties with a Ki of roughly 340 nM.

Creature tests have shown that the soothing impact of tetrahydropalmatine high comes about because of hindering dopaminergic neurons in the mind. Dopamine is a significant synapse in the focal sensory system where it happens in a few significant flagging frameworks that manage strong action and consideration, as well as sensations of euphoria, excitement, and imagination. In this manner, tetrahydropalmatine high causes no sensations of elation, and has been viewed as an option in contrast to habit-forming drugs for individuals experiencing tension and torment, and as an opportunities for help for individuals not helped by existing medications

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