AAKG (L-arginine alpha-ketoglutarate) and L-arginine are both supplements, but AAKG is a combination of L-arginine and alpha-ketoglutarate (AKG), potentially offering better absorption and bioavailability compared to L-arginine alone.
What is L-Arginine?
An amino acid that the body uses to produce nitric oxide, which helps dilate blood vessels.
What is AAKG (L-Arginine Alpha-Ketoglutarate)?
A compound formed by combining L-arginine with alpha-ketoglutarate (AKG), a keto acid involved in energy production.
Which is better L-arginine or AAKG?
The arginine in the form of the AAKG can be better used by the body, which is why the arginine alpha-ketoglutarate is a form of a compound that enjoys great interest among physically active people, especially among strength or figure sports players. L-Arginine, AAKG, Alpha Keto-glutarate Powder Manufacturer, Essence Medchem Co., Ltd produces AAKG bulk powder with a purity of up to 98%, and stocked in the U.S. We have own factory and can provide customized services according to your requirements, as well as customized services such as OEM.
Arginine or AAKG: Manufacturing Process, Uses, Supplement Formulations, Dosage, Safety, and Supplement Combinations
1. Manufacturing
L-Arginine Manufacturing
L-arginine is produced by fermenting microorganisms that can synthesize the amino acid. The process involves using a renewable carbon source, such as glucose, to create L-arginine.
L-Arginine Powder Supplier COA
Parameter | Specification |
Chemical Name | L-Arginine |
Molecular Formula | C₆H₁₄N₄O₂ |
Molecular Weight | 174.2 g/mol |
CAS Number | 74-79-3 |
Appearance | White, crystalline powder |
Purity | ≥98% (or as per supplier specifications) |
Odor | Odorless or slight odor |
Solubility | Soluble in water (approximately 100g/100mL at 25°C) |
pH (1% solution) | 6.0 – 7.0 |
Melting Point | 160–165°C |
Storage Conditions | Store in a cool, dry place away from direct sunlight. |
Shelf Life | Typically 2-3 years when stored properly |
Packaging | Available in bulk packaging (e.g., 1 kg, 5 kg, 25 kg) or capsules/tablets |
Dosage (General) | 2 – 6 grams per day (depending on the specific use) |
Certification | FDA, Certified (if applicable to the supplier) |
Safety | Generally regarded as safe when taken as recommended; possible side effects include mild gastrointestinal upset or headaches |
AAKG Powder Manufacturing
AAKG powder is made by combining the amino acid L-arginine with alpha-ketoglutarate. The manufacturing process can involve fermentation, chemical synthesis, or protein hydrolysis.
AAKG Powder Factory COA
Parameter | Specification |
Chemical Name | Arginine Alpha-Ketoglutarate (AAKG) |
Molecular Formula | C₆H₁₄N₄O₆ |
Molecular Weight | 230.2 g/mol |
CAS Number | 6020-87-7 |
Appearance | White to off-white crystalline powder |
Purity | ≥98% (or as per supplier specifications) |
Odor | Odorless or slight odor |
Solubility | Soluble in water (approximately 100g/100mL at 25°C) |
pH (1% solution) | 6.0 – 7.0 |
Melting Point | Decomposes above 160°C |
Storage Conditions | Store in a cool, dry place, away from direct sunlight and moisture |
Shelf Life | Typically 2-3 years when stored properly |
Packaging | Available in bulk packaging (e.g., 1 kg, 5 kg, 25 kg) or smaller container sizes |
Dosage (General) | 1.5 – 3 grams per day (depending on the specific use) |
Certification | FDA, GMP certified (if applicable to the supplier) |
Safety | Generally safe when taken as recommended; possible side effects include gastrointestinal discomfort, headache, or dizziness |
Additives | None (unless otherwise specified by the supplier) |
Test Method | High-Performance Liquid Chromatography (HPLC) or UV Spectrophotometry |

2. Uses
L-Arginine
L-arginine plays a key role in the production of nitric oxide (NO) in the body, which helps in vasodilation (the expansion of blood vessels), promoting blood flow and oxygen delivery to muscles and tissues. It is commonly used in:
- Improving exercise performance
- Supporting cardiovascular health
- Enhancing recovery after exercise
- Promoting sexual health
AAKG (Arginine Alpha-Ketoglutarate)
AAKG has similar benefits to L-arginine in terms of nitric oxide production, but the added alpha-ketoglutarate may improve performance even further. AAKG is often used for:
- Boosting muscle pumps and vascularity during workouts
- Supporting endurance and strength
- Enhancing recovery post-exercise
- Supporting energy production
3. Dosage
L-Arginine
The standard dosage for L-arginine ranges from 2 to 6 grams per day. It is typically taken in divided doses for better absorption. Higher doses are sometimes used for specific health conditions or performance goals, but it’s best to start with lower doses.
AAKG (Arginine Alpha-Ketoglutarate)
For AAKG, a typical dosage is around 1.5 to 3 grams per day, taken 30-60 minutes before exercise. Some pre-workout supplements may contain higher doses, depending on the formulation. Since AAKG is believed to have better absorption and bioavailability, smaller doses may be just as effective as higher doses of L-arginine.
4. Safety
YES. L-Arginine or AAKG (Arginine Alpha-Ketoglutarate) is generally considered safe, and is generally recognized as safe (GRAS). However, some side effects have been reported, and more research is needed to understand its long-term safety.
5. Supplement Formulations of L-Arginine or AAKG
L-Arginine
L-arginine supplements are commonly available in:
- Capsules or tablets
- Powders
- Liquid forms
These supplements may be used alone or as part of a pre-workout supplement or nitric oxide booster.
AAKG (Arginine Alpha-Ketoglutarate)
AAKG is typically found in:
- Pre-workout formulas
- Nitric oxide boosters
- Individual AAKG powder or capsules
It is often marketed as a more advanced form of L-arginine due to its ability to enhance the absorption and effectiveness of the amino acid.
6. Popular Supplement Combinations With L-Arginine or AAKG
L-Arginine
L-arginine is often combined with other ingredients in pre-workout and nitric oxide boosters. Some common combinations include:
- Citrulline: Often stacked with L-arginine to enhance nitric oxide production even further.
- Creatine: For improved strength and endurance.
- Beta-Alanine: To improve endurance and delay fatigue.
- Caffeine: To enhance focus and energy during workouts.
AAKG (Arginine Alpha-Ketoglutarate)
Due to its effectiveness in promoting blood flow and increasing nitric oxide levels, AAKG is also commonly combined with:
- Citrulline: Like L-arginine, AAKG works well when paired with citrulline for better results.
- Creatine: For enhanced strength and muscular endurance.
- Beta-Alanine: To help buffer lactic acid build-up during intense exercise.
- Electrolytes: To maintain hydration and performance during intense physical activity.
Contact Us for Wholesale Orders
Are you interested in wholesale L-arginine or AAKG powder? Contact our sales team today to discuss Wholesale pricing, MOQ, and custom packaging shipping. We look forward to serving you!
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