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  • Chemical Name: Benfotiamine
  • CAS No.: 22457-89-2
  • MF: C19H23N4O6PS
  • MW: 466.45
  • Purity: ≥98% or according to customer requested
  • Product Categories: Pharmaceutical raw materials; Pharma intermediates; Pharmaceutical
  • Test method: HPLC

Benfotiamine is a thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation. It has a role as an immunological adjuvant, a nutraceutical, an antioxidant, a provitamin B1 and a protective agent. It is an aminopyrimidine, a member of formamides, an organic phosphate and a thioester. It derives from a thiamine(1+).

Basic Information
Product Name: Benfotiamine
Synonyms: Benfotiamine powder, benfotiamine, Benfotiamina
CAS: 22457-89-2
MF: C19H23N4O6PS
MW: 466.45
EINECS: 245-013-4
Product Categories: Pharmaceutical raw materials; Pharma intermediates; Pharmaceutical
Chemical Structure


Chemical Properties
Melting point 165 C
Boiling point 745.1±70.0 °C(Predicted)
density 1.444±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 1.84±0.10(Predicted)
Benfotiamine benefits

Benfotiamine is a fat-soluble derivative of thiamine, which has a higher bioavailability than thiamine, but it must be dephosphorylated by alkaline phosphatase to become a fat-soluble precursor before it can pass through the cell membrane. Biological effects. Clinically, it is mainly used for the treatment of diabetic complications, especially for Chemicalbook treatment and prevention of diabetic retinopathy. Compared with other derivatives of thiamine, this product is absorbed more quickly and completely after oral administration. After being absorbed into the systemic circulation, benfotiamine is rapidly metabolized to thiamine but does not increase the concentration of the drug in the brain. At the same time, hippuric acid is produced and excreted in the urine.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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