Benfotiamine is a thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation. It has a role as an immunological adjuvant, a nutraceutical, an antioxidant, a provitamin B1 and a protective agent. It is an aminopyrimidine, a member of formamides, an organic phosphate and a thioester. It derives from a thiamine(1+).
Benfotiamine is a fat-soluble derivative of thiamine, which has a higher bioavailability than thiamine, but it must be dephosphorylated by alkaline phosphatase to become a fat-soluble precursor before it can pass through the cell membrane. Biological effects. Clinically, it is mainly used for the treatment of diabetic complications, especially for Chemicalbook treatment and prevention of diabetic retinopathy. Compared with other derivatives of thiamine, this product is absorbed more quickly and completely after oral administration. After being absorbed into the systemic circulation, benfotiamine is rapidly metabolized to thiamine but does not increase the concentration of the drug in the brain. At the same time, hippuric acid is produced and excreted in the urine.
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