Biapenem side chain is a pharmaceutical raw material that can be used to produce Biapenem antibiotics. Biapenem (LJC 10627) is a carbapenem antibiotic for injection developed by Japanese Lederle Company and American Cyanamid Company in 1989. It is now completed in Phase III clinical studies in Japan and waits for approval. The most significant feature of this product is that the S in 2-position has bicyclic triazole 1β-methyl carbapenem. The study of structure-activity relationship shows that the presence of the side chain quaternary ammonium cation center is the key to affect the permeability of the outer membrane, so that its ability to inhibit the activity of pseudomonas aeruginosa and anaerobic bacteria is 2~4 times that of imipenem, its ability to inhibit the activity of drug-resistant pseudomonas aeruginosa is 4 to 8 times that of Meropenem, and its effect on acinetobacter and anaerobic bacteria is more effective than ceftazidime.
| Product Name: | BIAPENEM SIDE CHAIN |
| Synonyms: | 6-sulfanyl-5H,6H,7H-2,4000000$l^{5},8000000-pyrazolo[1,2-a][1$l^{5},2,4]triazol-4-yliuM chloride; 6,7-dihydro-6-mercapto-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride; 6,7-DIHYDRO-6-MERCAPTO-5H-PYRAZOLO(1,2-A) (1,2,4)-TRIAZOLIUM CHLORIDE; 5H-PYRAZOLO[1,2-A][1,2,4]TRIAZOL-4-IUM, 6,7-DIHYDRO-6-MERCAPTO-, CHLORIDE; Biapenem Side; 6-MERCAPTO-6,7-DIHYDRO-5H-PYRAZOLO[1,2-A][1,2,4]TRIAZOL-4-YLIUM; Side chain for biapenem, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium chloride, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium,; Side chain for Biapenem |
| CAS: | 153851-71-9 |
| MF: | C5H8ClN3S |
| MW: | 177.66 |
| EINECS: | 604-929-8 |
| Product Categories: | API intermediates; (the sidechain of biapenem); Chemical intermediate for Biapenem; Other Products; Pharmaceutical intermediate |
| Mol File: | 153851-71-9.mol |
| Melting point | 127-128 °C (decomp) |
| CAS DataBase Reference | 153851-71-9(CAS DataBase Reference) |
Appearance: white to yellowish crystalline powder
Determination of content: 98%
Specific rotation: -26.0 ° to-36.0 °
PH: 4.5 to 6.0
Single Impurity: <1.0%
Total Impurities: <3.0%
Tetrahydrofuran and acetone: tetrahydrofuran less than 0.072%, acetone less than 0.5%
Loss on drying: no more than 1.0%
Residue on ignition: no more than 0.2%
Heavy metals: no more than 20ppm
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
Biapenem side chain is a pharmaceutical raw material that can be used to produce Biapenem antibiotics. Biapenem (LJC 10627) is a carbapenem antibiotic for injection developed by Japanese Lederle Company and American Cyanamid Company in 1989. It is now completed in Phase III clinical studies in Japan and waits for approval. The most significant feature of this product is that the S in 2-position has bicyclic triazole 1β-methyl carbapenem. The study of structure-activity relationship shows that the presence of the side chain quaternary ammonium cation center is the key to affect the permeability of the outer membrane, so that its ability to inhibit the activity of pseudomonas aeruginosa and anaerobic bacteria is 2~4 times that of imipenem, its ability to inhibit the activity of drug-resistant pseudomonas aeruginosa is 4 to 8 times that of Meropenem, and its effect on acinetobacter and anaerobic bacteria is more effective than ceftazidime.
| Product Name: | BIAPENEM SIDE CHAIN |
| Synonyms: | 6-sulfanyl-5H,6H,7H-2,4000000$l^{5},8000000-pyrazolo[1,2-a][1$l^{5},2,4]triazol-4-yliuM chloride; 6,7-dihydro-6-mercapto-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride; 6,7-DIHYDRO-6-MERCAPTO-5H-PYRAZOLO(1,2-A) (1,2,4)-TRIAZOLIUM CHLORIDE; 5H-PYRAZOLO[1,2-A][1,2,4]TRIAZOL-4-IUM, 6,7-DIHYDRO-6-MERCAPTO-, CHLORIDE; Biapenem Side; 6-MERCAPTO-6,7-DIHYDRO-5H-PYRAZOLO[1,2-A][1,2,4]TRIAZOL-4-YLIUM; Side chain for biapenem, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium chloride, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium,; Side chain for Biapenem |
| CAS: | 153851-71-9 |
| MF: | C5H8ClN3S |
| MW: | 177.66 |
| EINECS: | 604-929-8 |
| Product Categories: | API intermediates; (the sidechain of biapenem); Chemical intermediate for Biapenem; Other Products; Pharmaceutical intermediate |
| Mol File: | 153851-71-9.mol |
| Melting point | 127-128 °C (decomp) |
| CAS DataBase Reference | 153851-71-9(CAS DataBase Reference) |
Appearance: white to yellowish crystalline powder
Determination of content: 98%
Specific rotation: -26.0 ° to-36.0 °
PH: 4.5 to 6.0
Single Impurity: <1.0%
Total Impurities: <3.0%
Tetrahydrofuran and acetone: tetrahydrofuran less than 0.072%, acetone less than 0.5%
Loss on drying: no more than 1.0%
Residue on ignition: no more than 0.2%
Heavy metals: no more than 20ppm
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
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