Dihydromyricetin As A Dietary Supplement to Improve Blood Sugar: Ingredient Guide

Dihydromyricetin (DHM) a natural flavonoid primarily extracted from Ampelopsis grossedentata, has garnered significant attention in the nutraceutical industry for its potential benefits in managing blood sugar levels. This comprehensive overview provides insights into its sourcing, manufacturing, benefits, dosage, formulation, and solubility.

Source & Manufacturing Process

Botanical Origin: DHM is predominantly derived from Ampelopsis grossedentata, a plant native to China

Extraction & Purification

1. Traditional Methods: Involve hot water extraction followed by filtration and concentration

2. Advanced Techniques: Chelating extraction using Zn²⁺ ions has been developed to enhance purity and yield.

3. Industrial Production: Employs plant extraction, chemical synthesis, or biotransformation to optimize purity and scalability.

We supply high-purity Dihydromyricetin (>98%) is preferred for supplement formulations to ensure efficacy and safety.

What is the Solubility of Dihydromyricetin?

Dihydromyricetin (DHM) has limited solubility in water particularly at room temperature, with a solubility of around 0.2-0.7 mg/mL at 25°C. However, its solubility increases significantly in hot water, reaching approximately 16.0 mg/mL at 100°C. It is more soluble in organic solvents like ethanol, DMSO, and DMF.

Health Benefits for Blood Sugar Management

Enhances Glucose Uptake: DHM promotes glucose uptake in adipocytes by inhibiting the MEK/ERK pathway, leading to improved insulin sensitivity.

Reduces Fasting Blood Glucose & HbA1c: Animal studies demonstrate that DHM administration significantly lowers fasting blood glucose and HbA1c levels, indicating improved glycemic control.

Improves Insulin Resistance: DHM upregulates IRS-1 (Y612) tyrosine phosphorylation, enhancing insulin signaling pathways.

Modulates Lipid Profiles: Studies have linked DHM treatment to decreased serum total cholesterol and triglyceride levels, which contributes to overall metabolic health.

Dosage Guidelines

Animal Studies:

Effective Doses: 0.5 to 1.0 g/kg body weight per day have shown significant metabolic benefits in rodent models.

Human Studies:

Clinical Trial: A randomized controlled trial administered 970 mg/day of DHM to individuals with type 2 diabetes, resulting in a notable decrease in fasting glucose levels.

Dihydromyricetin presents a promising natural compound for blood sugar management, with multiple studies supporting its efficacy in enhancing glucose uptake, improving insulin sensitivity, and modulating lipid profiles. However, challenges related to its solubility necessitate advanced formulation strategies to maximize its bioavailability. For B2B stakeholders, focusing on high-purity sourcing, innovative delivery systems, and regulatory compliance will be key to successfully integrating DHM into health supplement portfolios.

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