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Doripenem Hydrate
- Chemical Name: Doripenem hydrate
- CAS No.: 364622-82-2
- MF: C15H26N4O7S2
- MW: 438.51
- Specification: USP|EP|BP
- Purity:98%，99% or As customer requested
- Appearance: white to beige
- Solubility：H2O: soluble5mg/mL, clear (warmed)
- Product Categories: Inhibitors
- Test method: HPLC
Description
What is Doripenem Hydrate?
Doripenem Hydrate (S-4661) is an ultra-broad-spectrum injectable antibiotic, used to treat complicated intra-abdominal infections and complicated urinary tract infections.
In vitro
Doripenem Hydrate is active against Aeromonas (MIC50, 0.03 mg/L), Bacillus spp. (MIC50, 0.03 mg/L) and all tested anaerobic species (MIC range, < or =0.015-4 mg/L), but is less active against S. maltophilia (MIC90, >32 mg/L) and Enterococcus faecium (MIC90, >32 mg/L) among the enterococcal species. Doripenem is the most active carbapenem (MIC90, 1 to 4 mg/mL) against penicillin-resistant streptococci.
Doripenem and doripenem hydrate is found to be highly active against oxacillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci (2705 and 297 isolates, respectively; MIC90s 0.06 mg/L), with a potency greater than that of other carbapenem antibiotics. Doripenem is among the most potent agents tested against Streptococcus pneumoniae, viridans group streptococci and beta-haemolytic streptococci (885, 140 and 397 isolates; MIC(90)s 0.5, 0.5 and 0.03 mg/L, respectively).
Doripenem Hydrate is also active against Citrobacter spp., Enterobacter spp. and Serratia spp. (MIC90s 0.06-0.25 mg/L), including ceftazidime-resistant isolates. Doripenem is slightly more potent (MIC50 2 mg/L) than ertapenem and imipenem (MIC50 4 mg/L), and has a potency similar to that of meropenem (MIC50 2 mg/L), against Burkholderia cepacia (20 isolates). [3] Doripenem demonstrates in vitro activity similar to that of meropenem against gram-negative pathogens and to that of imipenem against gram-positive pathogens.
Doripenem Monohydrate Basic information
| Product Name: | Doripenem hydrate |
| Synonyms: | (+)-(4r,5s,6s)-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-3-[[(3s,5s)-5-[(sulfamoylamino)-methyl]-3-pyrrolidinyl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate; doripenem hydrate; DoripeneM Crude; 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, hydrate; (4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; Doripenem monohydrate, >=99%; (4R,5S,6S)-6-((R)-1-Hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrroli; S 4661 monohydrate |
| CAS: | 364622-82-2 |
| MF: | C15H26N4O7S2 |
| MW: | 438.51 |
| EINECS: | 680-392-3 |
| Product Categories: | Doribax, Doripenem monohydrate, S-4661, Finibax; Inhibitors |
| Mol File: | 364622-82-2.mol |
Doripenem Hydrate Chemical Structure
Doripenem Monohydrate Chemical Properties
| Melting point | 173°C(dec.)(lit.) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble5mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| BRN | 15340136 |
| InChIKey | NTUBEBXBDGKBTJ-WGLOMNHJSA-N |
| CAS DataBase Reference | 364622-82-2(CAS DataBase Reference) |
Doripenem Hydrate Usage And Synthesis
Doripenem (doripenem monohydrate) is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It is particularly active against Pseudomonas aeruginosa.
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
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