Lincomycin is a lincosamide antibiotic derived from bacteria Streptomyces lincolnensis with activity against gram positive and anaerobic bacteria. Lincomycin binds to the 50S subunit of the bacterial ribosome resulting in the inhibition of protein synthesis and thereby produces bactericidal effects in susceptible organisms. (Source: NCI Thesaurus (NCIt))
Respiratory tract infections caused by Staphylococcus, Streptococcus pyogenes, pneumococcus and anaerobic bacteria, skin and soft tissue infections, female reproductive tract and pelvic infections, and abdominal cavity infections caused by anaerobic bacteria. In addition to the above indications, lincomycin injection can still be used for sepsis caused by streptococcus and staphylococcus, bone and joint infections, surgical adjuvant treatment of chronic bone and joint infections, and acute blood-borne bone marrow caused by staphylococci Yan etc. The concentration of lincomycin that penetrates into the cerebrospinal fluid cannot reach an effective level and is not suitable for the treatment of meningitis.
Lincomycin has dosage forms approved for use in dogs, cats, swine, and in combination with other agents for chickens. Because clindamycin is generally better absorbed, more active, and probably less toxic, it has largely supplanted the use of lincomycin for oral and injectable therapy in small animals, but some clinicians believe that clindamycin does not offer enough clinically significant improvements over lincomycin to justify its higher cost. For further information, refer to the Pharmacology or Doses sections.
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