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  • Chemical Name: Erdosteine
  • CAS No.: 84611-23-4
  • MF: C8H11NO4S2
  • MW: 249.31
  • Purity: ≥98% or according to customer requested
  • Color: white
  • Product Categories: Pharmaceutical intermediate;Bulk Drug Intermediates;Asthma drugs;APIs;Respiratory Drugs
  • Test method: HPLC

What is Erdosteine?

Erdosteine is a drug that causes a breakdown of mucus, also known as a mucolytic agent. It is a thiol derivative produced for the clinical management of chronic obstructive bronchitis, in addition to infective exacerbations of chronic bronchitis. This drug contains sulfhydryl groups which are released after erdosteine undergoes hepatic first pass metabolism. Three active metabolites result and possess mucolytic activity in addition to free radical scavenging activity. Erdosteine acts to control mucus production and control its viscosity while increasing mucociliary transport. 

It also combats the effects of free radicals resulting from cigarette smoke. Erdosteine has been shown to be safe and well tolerated in clinical trials. Erdosteine 300mg twice daily reduced cough (both frequency and severity) and sputum viscosity more quickly and more effectively than placebo and reduced the adhesivity of sputum more effectively than ambroxol 30mg twice daily. Co-administration of erdosteine and amoxicillin in patients with acute infective exacerbation of chronic bronchitis resulted in higher concentrations of the antibiotic in the sputum, leading to earlier and more pronounced amelioration of clinical symptoms compared with placebo. Erdosteine is associated with a low incidence of adverse events, most of which are gastrointestinal and generally mild.

Basic information   
Product Name: Erdosteine
Synonyms: Erdosteinum; Erdosteine 98
CAS: 84611-23-4
MF: C8H11NO4S2
MW: 249.31
EINECS: 642-172-5
Product Categories: Pharmaceutical intermediate;Bulk Drug Intermediates;Asthma drugs;APIs;Respiratory Drugs
Chemical Structure


Chemical Properties
Melting point 156-160°C
Boiling point 590.4±50.0 °C(Predicted)
density 1.48±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
pka 3.71(at 25℃)
λmax 236nm(H2O)(lit.)
Erdosteine Uses

  1. Dissolving sputum: The molecule contains closed sulfhydryl groups, which are biotransformed into active metabolites containing free sulfhydryl groups in the liver. The latter can break glycoprotein disulfide bonds in bronchial secretions and reduce the viscosity of sputum. , So as to facilitate the discharge of sputum.

  2. Antioxidant for Chemicalbook: α1 antitrypsin in alveolar tissue can inhibit the hydrolysis of elastin by elastase. This product can protect α1 antitrypsin to avoid its inactivation due to free radical oxidation. In addition, this product also has the functions of enhancing the penetration of antibiotics and increasing mucociliary movement.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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