Neomycin Sulfate

Description

Neomycin Sulfate is the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death. (Source: NCI Thesaurus (NCIt))

Neomycin sulfate Basic information

Product Name:	Neomycin sulfate
Synonyms:	NEOMYCIN SULPHATE pure; mycigient; neobiotic; neofracin; neo-mantlecreme; neomix; neomycine sulfate; newfrancef
CAS:	1405-10-3
MF:	C23H48N6O17S
MW:	712.72
EINECS:	215-773-1
Product Categories:	13C & 2H Sugars; Biochemistry; Antibiotic Explorer; Carbohydrates & Derivatives; Aminoglycosides Alphabetic; Antibiotics;Chemical Structure;A minoglycosides Antibiotics; Antibacterial; Peptide Synthesis/Antibiotics; APIs
Mol File:	1405-10-3.mol

Framycetin sulfate Chemical Structure

Neomycin sulfate

Framycetin sulphate Chemical Properties

Melting point	>187°C (dec.)
alpha	D20 +54° (c = 2 in H2O)
refractive index	56 ° (C=10, H2O)
Fp	56℃
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
form	powder
color	white to slightly yellow
PH	5.0-7.5 (50g/l, H2O, 20℃)
Water Solubility	Soluble in water
Merck	14,6454
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	OIXVKQDWLFHVGR-VTSVPHRWSA-N
CAS DataBase Reference	1405-10-3(CAS DataBase Reference)
EPA Substance Registry System	Neomycin sulfate (1405-10-3)

Neomycin sulphate Usage And Synthesis

Chemical Properties	NEOMYCIN SULFATE is white or yellowish-white powder, hygroscopic.
Uses	NEOMYCIN SULFATE is an aminoglycoside antibiotic found in many topical medications. NEOMYCIN SULFATE has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.
	NEOMYCIN SULFATE is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.
	Neomycin sulfate is an antibiotic (can be used effectively against most bacteria that cause skin, eye and outer ear infections); broad-spectrum antibiotic in topical creams, powders, ointments, eye and ear drops; systemic antibiotic and growth promotor in veterinary use.

Maxmedchem, a global supplier of Neomycin sulfate, 1405-10-3 offers for your requirements of RND / Development quantities or commercials, based on status of the product. We can also offer its intermediates with supportive technical package required for evaluation.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

Email us at: info@maxmedchem.com for more details.