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Erythromycin Estolate

  • Chemical Name:Erythromycin Estolate
  • CAS No.:3521-62-8
  • MF: C52H97NO18S
  • MW:1056.39
  • Specification: USP|EP|BP
  • Purity: 95%-99% or As customer requested
  • Appearance: White
  • Solubility:Freely soluble in organic solvents, practically insoluble in water /n
  • Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals
  • Test method: HPLC


Erythromycin Estolate is the lauryl sulfate ester of propionyl erythromycin, a broad-spectrum, topical macrolide antibiotic with antibacterial activity. Erythromycin estolate diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin estolate may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved. (Source: NCI Thesaurus (NCIt))

Ilosone Basic information   

Product Name: Erythromycin Estolate
Synonyms: eritroger;eromycin;erythromycin,propionate(ester),compd.withmonododecylsulfate(1:1);erythromycin5-(3-propionate)dodecylsulfate;erythromycinpropionate,compd.withdodecylsulfate;erythromycinpropionatelaurylsulfate;ERYTHROMYCIN ESTOLATE;ERYTHROMYCIN 2′-PROPANOATE DODECYL SULFATE SALT
CAS: 3521-62-8
MF: C52H97NO18S
MW: 1056.39
EINECS: 222-532-4
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals
Mol File: 3521-62-8.mol

Lauromicina Chemical Structure

Erythromycin Estolate           

Estomicina Chemical Properties    

Melting point  135-140°C dec.
Boiling point  743℃
density  1.0053 (rough estimate)
refractive index  1.6550 (estimate)
Fp  >110°(230°F)
storage temp.  -20°C Freezer
solubility  chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform)
pka 6.9(at 25℃)
form  neat
color  white
Water Solubility  Freely soluble in organic solvents, practically insoluble in water /n
Sensitive  Light Sensitive
CAS DataBase Reference 3521-62-8

Erythromycin Estolate Usage And Synthesis

Uses Used as an antibacterial agent. LD50 >5000 mg/kg for oral administration to rats
Macrolides Antibiotics
Manufacturing Process 16.7 grams of monopropionylerythromycin are dissolved in 50 ml of warm acetone. To the solution are added 6.4 grams of sodium lauryl sulfate dissolved in 50 ml of distilled water containing 2 ml of glacial acetic acid. The white crystalline precipitate of rnonopropionylerythromycin lauryl sulfate which separates is filtered off and dried. It melts at about 135° to 137°C.
Therapeutic Function Antibacterial

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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