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Fidaxomicin(873857-62-6)C52H74Cl2O18

  • Chemical Name:Fidaxomicin
  • CAS No.:873857-62-6
  • MF: C52H74Cl2O18
  • MW:1058.04
  • Purity:≥98% or according to customer requested
  • Product Categories: API; Intermediates & Fine Chemicals; Pharmaceuticals
  • Test method: HPLC
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What is Fidaxomicin?

Fidaxomicin, also known as lipiarmycin and tiacumicin, is an 18-membered macrolide natural product that was first reported in mid-1970s and is produced by fermentation. Fidaxomicin and its primary metabolite OP-1118, which results from hydrolysis of the isobutyryl ester, are narrowspectrum antibacterial agents with activity against gram-positive aerobic and anaerobic organisms, but not against gram-negative organisms.

Basic information    
Product Name: FidaxoMicin
Synonyms: Tiacumicin B; Dificlir; Lipiarmycin; Lipiarmicin; Difimicin
CAS: 873857-62-6
MF: C52H74Cl2O18
MW: 1058.04
Product Categories: Fidaxomicin and Impurities; Inhibitors; Antibiotic; APIs; 
Chemical Structure

FidaxoMicin            

Chemical Properties
        
Melting point  161 °C
Boiling point  1046.4±65.0 °C(Predicted)
density  1.33
storage temp.  2-8°C
pka 5.09±0.35(Predicted)
form  powder
FidaxoMicin Uses And Synthesis           

Fidaxomicin is a recently marketed antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.


Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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