Glutamic acid can be used in medicine

Glutamic acid is one of the amino acids that constitute protein. Although it is not an essential amino acid for the human body, it can be used as carbon and nitrogen nutrition to participate in the body’s metabolism and has high nutritional value. After being absorbed by the human body, glutamic acid is easy to form glutamylamine with blood ammonia, which can relieve the poisonous effect of ammonia in the metabolic process, so it can prevent and treat hepatic coma and protect the liver.

It is an auxiliary medicine for patients with liver diseases. Brain tissue can only oxidize glutamate, but not other amino acids, so glutamine can be used as an energy substance in brain tissue to improve and maintain brain function. Glutamate, as a tonic for the nerve center and cerebral cortex, has certain effects on the treatment of concussions or nerve damage, epilepsy, and mentally retarded children. The patented medicines made with glutamate include medicinal glutamate tablets, sodium (potassium) glutamate injection, calcium glutamate injection, acetylglutamate injection and so on.

Downstream product development of Glutamic acid

Ethanol and L-glutamic acid are directly esterified to protect the carboxyl group, and activated with triphosgene to form the corresponding N-carboxylic anhydride, which can directly obtain poly-L-chloroethyl glutamate with a certain reactivity in the side chain.

There are one amino group and two carboxyl groups in the structure of glutamic acid. Under the action of phosgene, the carboxyl group and the amino group will form a cyclic N-carboxylic acid anhydride. Before the ring reaction, the carboxyl group is usually protected with benzyl alcohol. The side chain activity of the obtained polymer is very low. Generally, further hydrogenation debenzylation or amine debenzylation is required to obtain the reactive side chain. We use bifunctional The base reagent chloroethanol is used as a protective gene, and reactive side chains can be directly obtained after polymerization, which can effectively simplify the synthesis route.

The side chain esterification process is a reversible reaction. As the water content in the system continues to increase, the reaction rate will decrease, resulting in low yield. When the benzyl glutamate is formed, molecular sieve is used for dehydration, which greatly simplifies the operation. New polymerized amino acids, drugs containing amino groups or targeted genes, can be easily inserted into polyglutamic acid molecules to form macromolecular prodrugs or targeted macromolecular vectors, and access specific genes for special Separation or purification, this polymer will have a wide range of application prospects in the field of medicine.

Glutamic acid can produce many important downstream products such as sodium L-glutamate, polyglutamic acid and so on.

As far as I know, there are many additional products that related to Glutamic acid and as one of the suppliers of Glutamic acid, Maxmedchem has acknowledged the market demand of customers worldwide in order to make more contribution to the health of human society.

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