Histidine Essential Amino Acids

  • Chemical Name: L-Histidine
  • CAS No.:71-00-1
  • MF: C6H9N3O2
  • MW:155.15
  • Purity:>99% or As customer requested
  • Color:White to off-white or pale yellow
  • Product Categories: Amino Acids; Biochemistry; Nutritional Supplements
  • Test method: HPLC


What is Histidine Essential Amino Acids?

While circulating concentrations of histidine essential amino acids decrease in pathologic conditions (such as chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD), histidine is a nutritionally essential amino acid with numerous known health benefits. 

This review will look at the existing research on the benefits of taking histidine, the negative effects of too much of it, and the upper tolerance level for histidine. Supplementation with portions of 4.0-4.5 g histidine/d and expanded dietary histidine admission are related with diminished BMI, adiposity, markers of glucose homeostasis (e.g., HOMA-IR, fasting blood glucose, 2-h postprandial blood glucose), proinflammatory cytokines, and oxidative pressure.

Basic information  

Product Name: L-Histidine

L-histidine; Istidina; histidina; Histidinum; histidina

CAS: 71-00-1
MF: C6H9N3O2
MW: 155.15
EINECS: 200-745-3
Product Categories: Amino Acids; Biochemistry; Nutritional Supplements; alpha-Amino Acids; amino
Chemical Structure


Chemical Properties   

Melting point  282 °C (dec.)(lit.)
alpha  12.4 º (c=11,6N HCl)
Boiling point  278.95°C (rough estimate)
density  1.3092 (rough estimate)
refractive index  13 ° (C=11, 6mol/L HCl)
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
form  powder
pka 1.8(at 25℃)
color  White to off-white or pale yellow
PH 7.0-8.0 (25℃, 0.1M in H2O)
PH Range 7 – 8 at 15.5 g/l at 25 °C
optical activity [α]20/D 39±1°, c = 2% in H2O
Water Solubility  41.6 g/L (25 ºC)
λmax λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number 1431
Merck  14,4720
BRN  4673585
Stability: Stable. Incompatible with strong oxidizing agents.
Usage And Synthesis

Description White, odorless crystals or crystalline powder having a slightly bitter taste. It is soluble in water, very slightly soluble in alcohol, and insoluble in ether. It melts with decomposition between about 277° and 288°C.
Chemical Properties L-Histidine is an odorless powder with slightly bitter taste

Histidine Essential Amino Acids Uses

  1. May Aid in the Prevention of Chronic Diseases, including Heart Disease

    Histidine is transformed into carnosine, a “histidine-containing dipeptide” (HCD) found in heart muscle, skeletal muscle, and brain tissue. Through their anti-inflammatory, anti-oxidative, antiglycating, anti-ischaemic, and chelating properties, some studies have found that HCDs may prevent chronic diseases.

2. Reduces Fatigue 

According to some studies, people who are depressed have lower levels of brain histamine receptor binding, and the severity of their depression symptoms is correlated with this decrease. Anxiety symptoms may also be exacerbated by low histidine essential amino acid levels, according to animal studies. In mammals, it has been demonstrated that this amino acid can cross the blood–brain barrier. This suggests that taking histidine supplements may raise histamine levels in the brain and alleviate symptoms like mental exhaustion and lack of motivation.

3. Works on Mental Execution and Mental Wellbeing

Since it helps structure myelin sheath and shield cells from oxidative harm, histidina aminoacido may likewise guard against mental degenerative problems, like Alzheimer’s illness and Parkinson’s sickness.

4. Reduces Oxidative Stress, Inflammation, and Metabolic Syndrome 

Histidine supplementation has been shown to improve insulin sensitivity in obese adults with metabolic syndrome in a number of human and animal studies. According to a 2013 study, supplementing with this amino acid could suppress the expression of pro-inflammatory cytokines, reduce inflammation, and lower body mass index (BMI) and fat mass.

5. Can Protect and Heal Skin 

According to the Environmental Working Group, histamine is used in products that condition skin and hair to help reduce dryness and irritability. It is also sometimes used to alleviate the symptoms of eczema.

6. Can Protect Against Allergies and Infections

 When combined with zinc, histidine essential amino acids has been shown to protect against colds and shorten their duration. Additionally, taking histidine supplements may shorten the duration of viral or bacterial infections. Since it assumes a part in managing reactions of the resistant framework and creation of receptors, it might assist with diminishing seriousness of hypersensitive responses and fiery cycles too.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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