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Genistein(446-72-0)C9H9NO

  • Chemical Name:Genistein
  • CAS No.:446-72-0
  • MF:C9H9NO
  • MW:147.17
  • Purity:≥98% or according to customer requirements
  • Color: off-white
  • Product Categories: Inhibitors;Biochemistry;Natural Plant Extract;Flavonoids;pharmaceutical raw material;Pharmaceutical intermediate
  • Test method: HPLC
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What is Genistein?

Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (Source: NCI Thesaurus (NCIt))

Basic information   
Product Name: Genistein
Synonyms: prunetol; sophoricol; Genisterin; Genisteol; Synthetic Genistein; Genistein powder
CAS: 446-72-0
MF: C15H10O5
MW: 270.24
EINECS: 207-174-9
Product Categories: Inhibitors; Biochemistry; Natural Plant Extract; Flavonoids; pharmaceutical raw material; Pharmaceutical intermediate
Chemical Structure

Genistein           

Genistein Chemical Properties      
Melting point  297-298 °C
Boiling point  333.35°C (rough estimate)
density  1.2319 (rough estimate)
refractive index  1.6000 (estimate)
storage temp.  -20°C
solubility  DMSO: soluble
pka 6.51±0.20(Predicted)
form  powder
color  off-white
Water Solubility  insoluble
Merck  14,4391
BRN  263823
Stability: Light Sensitive
Usage And Synthesis 

Estrogenic effect

The estrogenic activity of genistein has been confirmed in many studies. Of all the isoflavones, genistein has the strongest estrogenic activity. The estrogenic effect of genistein may explain its protective action against osteoporosis and its possible effect on body weight reductions. Genistein is also used to ease menopause symptoms, such as hot flushes.
Antioxidant
Genistein is a strong antioxidant. Genistein removes damaging free radicals and reduces lipid peroxidation. Genistein increases the activity of other antioxidant enzymes such as glutathione peroxidase, superoxide dismutase and glutathione reductase. Studies have shown that genistein can also influence the growth of cells which are not hormone-dependent.
Anticancer
Genistein seems to reduce the risk for some hormone related cancers, principally breast cancer and prostate cancer. Epidemiological studies show that consumption of isoflavones may protect against breast and prostate cancer. High dietary intake of soy products China and Japan are linked with low incidence of these cancers. There are lots of theories to explain the anti-cancer action of genistein: inhibition of angiogenesis, inhibition of tyrosine kinases, antioxidant property, and anti-estrogen action (it is known that estrogen increases risk for certain cancers). Genistein binds with estrogen receptors, preventing the estrogen from binding and initiating cancer growth.
Heart health
Many in-vitro tests have demonstrated that genistein inhibits cellular cholesterol synthesis and cholesterol esterification. Genistein also reduces fatty acid oxidation and exerts lipid lowering effect. Only oxidized LDL cholesterol is absorbed by the arterial cells and prevention of this oxidation will reduce the risk for arteriosclerosis. Gensistein prevents the formation of hearth attacks and strokes by acting as anticlotting agent.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

Email us at: info@maxmedchem.com for more details.

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