Ibuprofen lysine and side effects

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, fever, and inflammation.This includes dysmenorrhea, migraines, and rheumatoid arthritis.It can also be used to close a patent ductus arteriosus in premature infants.It can be used orally or intravenously.It usually starts working within an hour.Common side effects include heartburn and rash.Compared with other NSAIDs, it may have other side effects such as gastrointestinal bleeding.It increases the risk of heart failure, kidney failure, and liver failure. At low doses, it does not appear to increase the risk of heart attack; however, at higher doses it does.Ibuprofen can also make asthma worse. While its safety in early pregnancy is unknown it appears to be harmful in late pregnancy and is therefore not recommended.Like other NSAIDs, it inhibits prostaglandin production by reducing cyclooxygenase (COX) activity.Ibuprofen is a weaker anti-inflammatory agent than other NSAIDs.Ibuprofen was discovered in 1961 by Stewart Adams and John Nicholson while working at Boots UK Limited and was originally marketed under the name Brufen.It has many trade names, including Nurofen, Advil, and Motrin.Ibuprofen was first marketed in the UK in 1969 and in the US in 1974.It is on the World Health Organization’s list of essential medicines.It is available as a generic drug. [6] In 2020, it was the 38th most commonly prescribed drug in the United States, with more than 16 million prescriptions filled.

Medical use 

Ibuprofen is mainly used to treat fever (including fever after vaccination), mild to moderate pain (including pain relief after surgery), dysmenorrhea, osteoarthritis, toothache, headache and pain caused by kidney stones. About 60% respond to any NSAID; A Cochran medical review of 51 trials of NSAIDs for low back pain found that “NSAIDs were effective in providing relief in patients with low back pain short-term symptoms. Acute low back pain”.For juvenile idiopathic arthritis, rheumatoid arthritis and other inflammatory diseases.

Also used for pericarditis and patent ductus arteriosus.

Ibuprofen lysine

In some countries, ibuprofen lysine (the lysine salt of ibuprofen, sometimes called “ibuprofen lysine”) is approved for the same conditions as ibuprofen; use lysine Amino acid salt because it is more soluble in water.Ibuprofen lysine is sold for rapid pain relief; given as a lysine salt, absorption is faster (35 minutes vs. 90-120 minutes).However, a 2020 clinical trial of 351 participants funded by Sanofi found no significant difference between ibuprofen and ibuprofen lysine in terms of ultimate onset of action or pain relief.In 2006, the U.S. Food and Drug Administration (FDA) approved ibuprofen lysine to close the patent ductus arteriosus in premature infants weighing between 500 and 1,500 grams (1 and 3 pounds) and up to 32 weeks’ gestation Age at which conventional medical management (eg, fluid restriction, diuretics, and respiratory support) is ineffective.

Side effects

Side effects include nausea, indigestion, diarrhea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.Rare adverse reactions include esophageal ulcers, heart failure, high blood potassium levels, renal impairment, confusion, and bronchospasm.Ibuprofen can worsen asthma, sometimes fatally.Hypersensitivity reactions, including anaphylaxis and anaphylactic shock, may occur.Ibuprofen can be quantified in blood, plasma, or serum to demonstrate the presence of the drug in individuals who have experienced anaphylaxis, to confirm a poisoning diagnosis in hospitalized patients, or to assist in forensic death investigations.A monograph has been published on ibuprofen plasma concentrations, timing of intake, and risk of nephrotoxicity in overdose users.In October 2020, the U.S.FDA required that the drug labels of all NSAID drugs be updated to describe the risk of oligohydramnios in unborn babies with kidney problems