Indole

Description

What is Indole?

Indole is a compound of pyrrole and benzene in parallel. Also known as benzopyrrole. There are two ways of merging, called indole and isoindole. Indole and its homologues and derivatives are widely found in nature, mainly in natural flower oils, such as jasmine, bitter orange, daffodil, vanilla, etc.

For example, indole was originally derived from the degradation of indigo; indole and its homologues also exist in coal tar; essential oils (such as jasmine essential oil, etc.) also contain indole; stool contains 3-methylindole; many urns Dyes are derivatives of indole; tryptophan, an essential amino acid for animals, is a derivative of indole; some natural substances with strong physiological activities, such as alkaloids and auxins, are all derivatives of indole. Indole is an imine, which is weakly basic; the double bond of the heterocyclic ring generally does not undergo addition reaction; dimerization and trimerization can occur under the action of strong acid.

Basic information

Product Name:	Indole
Synonyms:	FEMA 2593; INDOLE; 1-Azaindene; 1h indole; ketole; benzazole; indole powder; Benzopyrrole
CAS:	120-72-9
MF:	C8H7N
MW:	117.15
EINECS:	204-420-7
Product Categories:	Nutrition Research; Phytochemicals by Plant (Food/Spice/Herb);Pharma Intermediates; Heterocyclic Compounds; Organic Chemistry; Bulk Drug Intermediates

Chemical Structure

Indole

Chemical Properties

Melting point	51-54 °C (lit.)
Boiling point	253-254 °C (lit.)
density	1.22
vapor pressure	0.016 hPa (25 °C)
FEMA	2593 \| INDOLE
refractive index	1.6300
Fp	>230 °F
storage temp.	2-8°C
solubility	methanol: 0.1 g/mL, clear
pka	3.17 (quoted, Sangster, 1989)
form	Crystalline Powder
color	White to slightly pink
PH	5.9 (1000g/l, H2O, 20℃)
Odor	fecal odor, floral in high dilution
Odor Threshold	0.0003ppm
Water Solubility	2.80 g/L (25 ºC)
Sensitive	Light Sensitive
Merck	14,4963
JECFA Number	1301
BRN	107693

Usage And Synthesis

Chemical property

It is the shiny flaky white crystals, and would turn into dark colors when it exposed to light. There would be a strong unpleasant odor with high concentration of indole, but the flavor would change into oranges and jasmine after highly diluted (concentration <0.1%). It has the melting point of 52~53 ℃ and the boiling point of 253~254 ℃. It is soluble in alcohol, ether, hot water, propylene glycol, petroleum ether and most of the non-volatile oil, insoluble in glycerin and mineral oil.

Indole Uses

Natural indole are widely contained in neroli oil, orange oil, lemon oil, lime oil, citrus oil, peel oil, jasmine oil and other essential oil.

Natural products are widely contained in essential oils such as bitter neroli oil, sweet orange oil, lemon oil, white lemon oil, citrus oil, pomelo peel oil, and jasmine oil.

It can be widely used in jasmine, lilac, orange blossom, gardenia, honeysuckle, lotus, narcissus, ylang-ylang, grass blue, white orchid and other floral fragrances. A very small amount can be used in flavors such as chocolate, raspberry, strawberry, bitter orange, coffee, nuts, cheese, grape and fruity compounds.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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