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  • Chemical Name:L-Leucine
  • CAS No.:61-90-5
  • MF:C6H13NO2
  • MW:131.17
  • Purity: >98% or As customer requested
  • Color: White to Off-white
  • Product Categories: Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids; APIs; Biochemical Engineering
  • Test method: HPLC


What is L-leucine?

Leucine is one of nine essential amino acids in humans (provided by food), Leucine is important for protein synthesis and many metabolic functions. Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. Leucine is available in many foods and deficiency is rare.

L-leucine is the L-enantiomer of leucine. It has a role as a plant metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a human metabolite, an algal metabolite and a mouse metabolite. It is a pyruvate family amino acid, a proteinogenic amino acid, a leucine and a L-alpha-amino acid. It is a conjugate base of a L-leucinium. It is a conjugate acid of a L-leucinate. It is an enantiomer of a D-leucine. It is a tautomer of a L-leucine zwitterion. 

Basic information  

Product Name: L-Leucine
Synonyms: leucine; Leucin; Leucinum; L-leucin; Leucina; alpha-Aminoisocaproic acid
CAS: 61-90-5
MF: C6H13NO2
MW: 131.17
EINECS: 200-522-0
Product Categories: Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids; APIs; Biochemical Engineering
Chemical Structure


Chemical Properties   

Melting point  >300 °C (lit.)
alpha  15.4 º (c=4, 6N HCl)
Boiling point  122-134 °C(Press: 2-3 Torr)
density  1,293 g/cm3
vapor pressure  <1 hPa (20 °C)
refractive index  1.4630 (estimate)
Fp  145-148°C
storage temp.  2-8°C
solubility  1 M HCl: 50 mg/mL
pka 2.328(at 25℃)
form  powder
color  White to Off-white
PH 5.5-6.5 (20g/l, H2O, 20℃)
optical activity [α]20/D +15.5°, c = 2 in 6 M HCl
Water Solubility  22.4 g/L (20 C)
λmax λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
Sublimation  145-148 ºC
JECFA Number 1423
Merck  14,5451
BRN  1721722
Stability: Stability Moisture and light sensitive. Incompatible with strong oxidising agents.
Usage And Synthesis

L-Leucine Uses            
It is an Amino acid drug and used as amino acid infusion and comprehensive amino acid preparations. For the diagnosis and treatment of children with idiopathic high blood sugar and glucose metabolism disorders,bile liver disease associated with reduced secretion , anemia, poisoning, muscular dystrophy, poliomyelitis, neuritis and mental illness. Diabetes, cerebral vascular sclerosis and kidney disease associated with proteinuria and hematuria is contraindicated. Gastric and duodenal ulcer patients should not be served.
The product is used as a nutritional supplement,an amino acid infusion preparation and a comprehensive amino acid preparation,a hypoglycemic agent, a plant growth promoter.

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