Quercetin Powder

#1 Nutritional Factors Affecting Mental Health and Development

nutritional factors cognition

#2 Human Gut-Microbiome Interactions

Research has suggested that quercetin powder may prevent and reduce the symptoms of depression, possibly through both immune stimulation and the production of neuro-active compounds. Therefore, manipulating the microbial assemblages in the gut could represent a novel therapeutic for perinatal depression. The gut-brain axis mediates the interaction between bacterial communities in the intestine and neurological, immunological and endocrinological processes.

Microbial immune activation and neurotransmitter energy metabolism (e.g. dopamine, 5-Hydroxytryptophan (5-HT), a precursor for serotonin, γ-Aminobutyric acid (GABA), noradrenaline, and acetylcholine) can, directly and indirectly, influence brain function, especially through the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis releases corticosteroids (i.e., cortisol) and activates downstream neurons that secrete neurotransmitters (i.e., norepinephrine), which can then modulate the gut ecosystem via immune-mediated antimicrobial peptides. Importantly, many of these interactions can be inhibited by severing the vagus nerve, thus cutting the main communication link between brain and gut.

#3 Medical Implications:

The human microbiota consists of 100 trillion microorganisms and vastly outnumbers the human genetic repertoire. These microorganisms have been shown to affect a number of processes, including training the immune system to respond to infections and affecting reproductive health outcomes such as preterm births and post-partem depression. We continue to explore the intricate relationship between our microbiota and our health through our medical research with prominent universities throughout Chicago.

#4 Advances in Cognitive Research, Mapping & Delivery Systems

Recent developments in the fields of neuroscience, neuropsychology, and neurochemistry, along with technological advancements in in artificial intelligence (A.I.) and machine learning technology have led us to a greater understanding of workings of the human brain. However, it remains the greatest mystery – an electrical mass of biological matter weighing under 2kg is nevertheless the most complex system in the known universe. Manipulating the functions, inputs, and outputs of the brain has been a pastime of mankind since time immemorable.

Modern advances in medical technology and delivery systems include nanotechnology and liposomal delivery systems. These have ‘trickled down’ from pharmaceutical use and are becoming more widely available to the general population, allowing more people to alter their brains in new ways. We are constantly on the lookout for research and products pertaining to human peak cognition and altered states of consciousness. Inevitably, the next few decades will reveal more about the science of the mind than has been learned in all of history.

#5 (Past Research Topic) Microbial Biology of the Built Environment

Urbanization and our increasingly indoor lifestyle have deeply affected how we acquire and interact with our microbiota. At the Gilbert Lab, we are working to answer fundamental questions about our microbial interaction with built environments, including what factors influence their microbial communities and how microbes are transferred throughout these environments. Much of our research relies on longitudinal surveys, including our Home Microbiome Project, which recruited citizen scientists to collect samples of their home and skin microbiota over time, as well as our Hospital Microbiome Project, which collected samples from patients, hospital staff, and surfaces of a newly constructed hospital over the course of its first year.

Quercetin Pharmacological effects

Quercetin powder bulk can significantly inhibit the effect of cancer-promoting agent, inhibiting the growth of malignant cells in vitro, inhibiting the DNA, RNA, and protein synthesis of Ehrlich ascites tumor cells.
Quercetin has effects of inhibiting the platelet aggregation and the release effect of serotonin (5-HT) as well as inhibiting the platelet aggregation process which is induced by ADP, thrombin and platelet-activating factor (PAF) in which having the strongest inhibition effect on PAF. Moreover, it can also inhibit thrombin-induced the release of platelet 3H-5-HT of rabbit.

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