Mesna

Description

What is Mesna?

Mesna is a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (Source: NCI Thesaurus (NCIt))

Basic information

Product Name:	Mesna
Synonyms:	2-mercaptoethanesulfonic; 2-mercaptoethanesulfonic acid; monosodium salt; MERCAPTOETHANESULFONIC ACID SODIUM SALT; MESNA SODIUM SALT;mesnaum;MESNEX;MESNA
CAS:	19767-45-4
MF:	C2H5NaO3S2
MW:	164.18
EINECS:	243-285-9
Product Categories:	pharmaceutical intermediate;Bulk Drug Intermediates;Asthma drugs;APIs;Respiratory Drugs

Chemical Structure

Mesna

Chemical Properties

Melting point	>240°C dec.
storage temp.	2-8°C
solubility	Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane
form	neat
Water Solubility	Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml).

Mesna Uses

Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.

2-Mercaptoethanesulfonic acid sodium salt (Coenzyme M sodium salt, MESNA) is used as an antioxidant and cytoprotective agent in a wide variety of applications from protection from toxicity of therapeutic agents, such as cyclophosphamide to prevention from brain injury damage.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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