Posaconazole

Description

What is Posaconazole?

Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. (Source: NCI Thesaurus (NCIt))

Basic Information

Product Name:	Posaconazole
Synonyms:	Posaconazole SP; Posaconazole solution; Posaconazole (JAN/USAN/INN)
CAS:	171228-49-2
MF:	C37H42F2N8O4
MW:	700.78
EINECS:	682-747-8
Product Categories:	API; Intermediates & Fine Chemicals; Pharmaceuticals;Inhibitors

Chemical Structure

Posaconazole

Chemical Properties

Melting point	170-1720C
Boiling point	850.7±75.0 °C(Predicted)
density	1.36±0.1 g/cm3(Predicted)
Fp	9℃
storage temp.	-20°C
pka	14.72±0.20(Predicted)
form	powder
color	white to beige
optical activity	[α]/D -24 to -32°, c = 1.0 in chloroform-d
Merck	14,7602
InChIKey	RAGOYPUPXAKGKH-XAKZXMRKSA-N

Posaconazole Uses And Synthesis

Posaconazole is a potent triazole antifungal agent used in the prevention of invasive fungal infections due to aspergillosis and candida in high risk patients. Posaconazole therapy is associated with transient, asymptomatic serum aminotransferase elevations and is a suspected but rare cause of clinically apparent acute drug induced liver injury.

Posaconazole Clinical Use

-Invasive aspergillosis
-Fusarium infection
-Chromoblastomycosis and mycetoma
-Coccidioidomycosis
-Oropharyngeal candidosis
-Prophylaxis of invasive fungal infections in patients at serious risk
-With the exception of oropharyngeal candidosis and prophylaxis, use is presently restricted to patients with disease that is refractory to other antifungal drugs, or who are intolerant to them.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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