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Montelukast Sodium(151767-02-1)C35H35ClNNaO3S

  • Chemical Name:Montelukast sodium
  • CAS No.:151767-02-1
  • MF:C35H35ClNNaO3S
  • MW:608.17
  • Purity:≥98% or according to customer requested
  • Color: white to tan
  • Product Categories: pharmaceutical intermediate;Bulk Drug Intermediates;Asthma drugs;APIs;Respiratory Drugs
  • Test method: HPLC
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What is Montelukast Sodium?

Montelukast Sodium is the orally bioavailable monosodium salt of montelukast, a selective cysteinyl leukotriene receptor antagonist with anti-inflammatory and bronchodilating activities. Montelukast selectively and competitively blocks the cysteinyl leukotriene 1 (CysLT1) receptor, preventing binding of the inflammatory mediator leukotriene D4 (LTD4). Inhibition of LTD4 activity results in inhibition of leukotriene-mediated inflammatory events including: migration of eosinophils and neutrophils; adhesion of leukocytes to vascular endothelium, monocyte and neutrophil aggregation; increased airway edema; increased capillary permeability; and bronchoconstriction. The CysLT1 receptor is found in a number of tissues including spleen, lung, placenta, small intestine, and nasal mucosa, and in a variety of cell types including monocyte/macrophages, mast cells, eosinophils, CD34-positive hemopoietic progenitor cells, neutrophils and endothelial cells. (Source: NCI Thesaurus (NCIt))

Basic Information  
Product Name: Montelukast sodium
Synonyms: MONTELUKAST NA;MONTELUKAST SODIUM;Montelukast Sodium Salt; Montelukast sodium 98
CAS: 151767-02-1
MF: C35H35ClNNaO3S
MW: 608.17
EINECS: 604-813-7
Product Categories: pharmaceutical intermediate;Bulk Drug Intermediates;Asthma drugs;APIs;Respiratory Drugs
Chemical Structure

Montelukast sodium            

Chemical Properties
           
Melting point 115 °C(dec.)
storage temp. 2-8°C
solubility DMSO: ≥8mg/mL at 60°C
form powder
color white to tan
optical activity [α]/D +90 to +106° in methanol (c=1)
Montelukast sodium Uses

Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.

Montelukast is also a selective leukotriene receptor antagonist and has been approved for the oral administration treatment of asthma and allergic rhinitis. It is also a potent oral preparation that can significantly improve the inflammatory indicators. Biological determination of biochemistry and pharmacology has showed that montelukast sodium has a high affinity and selectivity to the CysLT1 receptors.


Maxmedchem, a global supplier of Montelukast sodium, 151767-02-1 offers for your requirements of RND / Development quantities or commercials, based on status of the product. We can also offer lots of intermediates with supportive technical package required for evaluation.


a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS,BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

Email us at: info@maxmedchem.com for more details.

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