Sodium Cloxacillin Monohydrate

Description

Cloxacillin Sodium is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity.

Cloxacillin Sodium binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis.

Sodium cloxacillin monohydrate Basic information

Product Name:	Sodium cloxacillin monohydrate
Synonyms:	bactopen; cloxacillin sodium monohydrate; CLOXACILLIN SODIUM SALT MONOHYDRATE;CLOXACILLIN SODIUM SALT HYDRATE;CLOXACILLIN SODIUM SALT N-HYDRATE;CLOXACILLIN SODIUM SALT HYDRATE VETRANAL;CLOXACILLIN SODIUM EPC
CAS:	7081-44-9
MF:	C19H19ClN3NaO6S
MW:	475.88
EINECS:	629-588-2
Product Categories:	Pharmaceutical raw chemicals; API; antibiotic; Biochemistry

Sodium cloxacillin monohydrate Chemical Structure

Cloxapen Chemical Properties

Melting point	170℃
Boiling point	689℃
Fp	>110°(230°F)
storage temp.	2-8°C
solubility	H2O: soluble50mg/mL
form	solid
Water Solubility	Soluble in water
Merck	13,2444
BRN	5403885

Cloxapen Usage And Synthesis

Chemical Properties	White or almost white, hygroscopic, crystalline powder.
Uses	Penicillin antibacterial.
Clinical Use	The chlorine atom ortho to the position of attachment of thephenyl ring to the isoxazole ring enhances the activity ofcloxacillin sodium, [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodium monohydrate (Tegopen), over that ofoxacillin, not by increasing its intrinsic antibacterial activitybut by enhancing its oral absorption, leading to higher plasmalevels. In almost all other respects, it resembles oxacillin.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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