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Quercetin – nutritional ingredient

Where could we find Quercetin?

Quercetin is a kind of polyhydroxy flavonoids with multiple biological activities and high medicinal value. Quercetin is widely found in the flowers, leaves and fruits of plants. More than 100 Chinese herbal medicines are known to contain quercetin, such as Sophora japonica, Sophora japonicus, paeononia, chrysanthemum, Tianjihuang, Plantago, mulberry , Agrimonia, Gynostemma, Gynostemma, Hawthorn, Hypericum perforatum, Cuscuta, Ginkgo biloba, Acanthopanax senticosus, Oldenlandia diffusa, Cockscomb, Houttuynia cordata, Emblic, Saururus chinensis, Guava leaves, Tangerine, Viola dianthus, weeping pot grass, etc.quercetol distributor - Maxmedchem

Quercetin is widely distributed in nature and has the effects of anti-oxidation and scavenging free radicals. It also has anti-cancer, anti-inflammatory, antibacterial, anti-viral, hypoglycemic and hypotensive, immune regulation and cardiovascular protection effects.

How about the effect of quercetin on the human body?

1. Quercetin and respiratory health

Quercetin has good expectorant and antitussive effects, and has a certain anti-asthmatic effect. It is used for the treatment of chronic bronchitis for a long time. The effect of quercetin on the health of the respiratory system is achieved through multiple pathways such as mucus secretion, antiviral, anti-fibrosis, and anti-inflammatory.

Quercetin also has a wide range of anti-fibrosis effects, including anti-fibrosis of liver, lung, heart and kidney. Its mechanism of action is more complicated, including inhibition of fibroblast proliferation, inhibition of collagen synthesis, prevention of oxidative damage, inhibition of angiogenesis, etc. .

2. Antioxidant function of quercetin

Free radicals are normal metabolites in the body. When the free radicals in the body are excessive and unbalanced, they may cause aging, inflammation, cancer, and cardiovascular and cerebrovascular diseases. Experiments have proved that flavonoids have good scavenging effects on free radicals and superoxide anions.

The antioxidant activity of quercetin protects the mucosal system in the following ways.

① Quercetin can prevent lipid oxidation, and it is important to protect the lipid bilayer of the cell wall of the gastrointestinal tract, because these cells are an important part of the body’s immune system;

②Quercetin may protect liver cells from alcohol-induced oxidative damage by reducing glutathione consumption, increasing antioxidant enzyme activity, and inhibiting lipid peroxidation. The protective effect is dose-dependent and time-dependent.

③ Quercetin increases the mucus secretion of gastric cells, and mucus polysaccharides form a buffer layer on the gastric mucosa, reducing the contact between gastric acid and the gastric wall.

Studies have found that supplementation of quercetin with feed can not only significantly increase the antioxidant capacity of animal peripheral blood, but also save and protect vitamin C and vitamin E, indicating that quercetin can be directly or indirectly absorbed in the body after intestinal absorption. Play an anti-oxidant effect.quercetine manufacturer - Maxmedchem

3. Anti-inflammatory effect

Quercetin can reduce the body’s immune response to allergens, inhibit IgE-mediated release of allergic mediators from mast cells and IgG-mediated histamine release.

Quercetin is an effective inhibitor of lipoxygenase and reduces the production of pro-inflammatory arachidonic acid metabolites. In addition, quercetin can reduce the entry of highly antigenic proteins, antigens, and sensitizing microorganisms into the body.

Neutrophils are the most important inflammatory cells in the body’s early inflammatory response, and they are at the core of the inflammatory response.

Quercetin has no obvious effect on neutrophil spontaneous apoptosis, but it can inhibit the delay of neutrophil spontaneous apoptosis caused by the inflammatory factor LPS; at the same time, quercetin also reduces neutrophil apoptosis. Sensitivity of inflammatory factors, so as to achieve the purpose of anti-inflammatory.

4. Antibacterial effect

Some famous scirntists used Escherichia coli and Staphylococcus aureus as experimental strains, and the results showed that quercetin has the best antibacterial effect on Staphylococcus aureus; its antibacterial effect on Bacillus coli is second; it has an antibacterial effect on Escherichia coli, Bacillus thuringiensis, Bacillus subtilis and Pseudomonas aeruginosa also have relatively obvious antibacterial effects; they have no antibacterial effect on Alternaria hominis. Quercetin has broad-spectrum antibacterial properties, and its antibacterial effect on Gram-negative bacteria is stronger than that of Gram-positive bacteria.

5. Skin color enhancement and skin protection

Research by Chinese Scientist ZHU YU found that the number of melanocytes increased significantly after external application of quercetin on the epidermis of guinea pigs, which increased the color of the back skin of brown-yellow guinea pigs, and promoted the proliferation of melanocytes and melanin synthesis.

In addition, quercetin can also interfere with the transcription of collagen at the mRNA level, and combined with radiation can significantly reduce the collagen synthesis of keloid fibroblasts cultured in vitro. Therefore, quercetin may become a new keloid treatment drug.quertine factory - Maxmedchem

6. Protect the cardiovascular system

The protective effect of quercetin on the cardiovascular system is mainly reflected in five aspects:

① Dilate blood vessels and lower blood pressure: For example, quercetin can inhibit the release of endothelin, reduce the tension of blood vessels, and thereby lower blood pressure.

② Prevention and treatment of coronary heart disease: Through animal experiments, it has also been found to reduce the incidence and mortality of myocardial infarction, and reduce blood sugar;

③ Reducing myocardial hypertrophy; Quercetin can significantly inhibit the increase in total protein content of cardiomyocytes caused by angiotensin II, can significantly increase SOD activity, reduce MDA content, and have a significant preventive effect on cardiomyocyte hypertrophy.

④ Inhibit the proliferation and hypertrophy of vascular smooth muscle cells;

⑤ Anti-thrombosis. Inhibition of thrombin causes the increase of platelet cytoplasmic free calcium [Ca2 +], which inhibits platelet activation and aggregation, thereby indirectly protecting the cardiovascular system, expanding arteries, lowering blood pressure, anti-arrhythmic, and inhibiting in vivo and in vitro Collagen, adenosine diphosphate, arachidonic acid (AA), etc. induce platelet aggregation and the release of 5-hydroxytryptamine (5-HT).

7. Anti-cancer effect

Quercetin has a very wide range of anti-cancer activity, against a variety of malignant tumors such as colon cancer, liver cancer, gallbladder cancer, stomach cancer, pancreatic cancer, breast cancer, ovarian cancer, cervical cancer, prostate cancer, bladder cancer, melanoma, neuroblasts Cell tumors, leukemia and other tumor cells have inhibitory effects, and also have good inhibitory effects on lung cancer, nasopharyngeal carcinoma, etc.

Quercetin has a variety of biological activities. In addition to the above, it also has the effects of hypoglycemic, antidiarrheal, antiviral, antithrombotic, anti-obesity, and anti-depressive effects. As one of the factory supplier of Quercetin, Maxmedchem could supply both natural Quercetin and Synthetic Quercetin with competitive price. In addition, the supplier could offer COA or MSDS together with free samples for customers’ testing.

Are you looking for Quercetin powder or Quercetin in bulk used for Quercetin supplements production?

Contact us at: info@maxmedchem.com now!

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