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Vancomycin Hydrochloride (1404-93-9) C66H76Cl3N9O24

  • Chemical Name:Vancomycin hydrochloride
  • CAS No.:1404-93-9
  • MF: C66H76Cl3N9O24
  • MW:1485.71
  • Specification: USP|EP|BP
  • Purity: 98%-99% or As customer requested
  • Appearance: colorless to faint yellow or tan
  • Water Solubility:Soluble in water. Slightly soluble in methanol, ethanol and dimethylsulfoxide.
  • Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antibiotics and Antimycotics;
  • Test method: HPLC

Vancomycin Hydrochloride is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis. (Source: NCI Thesaurus (NCIt))

Vancomycin hydrochloride Basic information   

Product Name: Vancomycin hydrochloride
Synonyms: vancocinehydrochloride; LYPHOCIN; Vancomycin Hydrochloride (4 vials, each vial contains 99,300 mcg of vancomycin activity);Vancomycin Hydrochloride (4 vials, each vial contains 100,500 mcg of vancomycin activity);VANCOMYCIN, HYDROCHLORIDE, STREPTOMYCES ORIENTALIS;VANCOR;VANCOCIN;VANCOCIN HYDROCHLORIDE
CAS: 1404-93-9
MF: C66H76Cl3N9O24
MW: 1485.71
EINECS: 604-193-8
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antibiotics and Antimycotics;
Mol File: 1404-93-9.mol

Vancomycin hcl Chemical Structure

Vancomycin hydrochloride            

Vancomycin hcl Chemical Properties


Melting point  >190°C (dec.)
alpha  [α]D20 -30~-40゜ (c=1, H2O)
Fp  87℃
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, yellow
form  Powder
color  colorless to faint yellow or tan
PH pH (50g/l, 25℃) : 2.5~4.5
Water Solubility  Soluble in water. Slightly soluble in methanol, ethanol and dimethylsulfoxide.
Sensitive  Hygroscopic
Merck  13,9995
BRN  3704657

Aerovanc Usage And Synthesis

Uses It has a narrow antimicrobial spectrum which is mainly against Gram-positive bacteria.
It is a kind of narrow-spectrum antibiotics only effective in treating gram-positive bacteria, such as Streptococcus pneumoniae, Neisseria gonorrhoeae and enterococci; etc which are all sensitive to this drug. Staphylococcus aureus is particularly sensitive to this product. Its mechanism of action is inhibition of bacterial cell wall synthesis; it mainly binds to the bacterial cell wall and leaving some kinds of amino acids being unable to enter into the glycopeptides of the cell wall.
Chemical Properties off white powder
Uses Amphoteric glycopeptide antibiotic produced by Streptomyces orientalis discovered in soil. Inhibits bacterial cell wall synthesis by binding to peptidoglycan. Antibacterial.
Uses Vancomycin hydrochloride is the salt of a glycopeptide antibiotic isolated from Amycolatopsis orientalis in 1956. Vancomycin exhibits potent activity against Gram positive bacteria and is highly effective against MRSA in vitro and in vivo. Vancomycin interferes with cell wall synthesis by binding to D-alanine-D-alanine residues.

MSDS: MSDS available

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