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2-Aminothiazol-4-acetic Acid

  • Chemical Name: 2-Aminothiazol-4-acetic acid
  • CAS No.:29676-71-9
  • MF:C5H6N2O2S
  • MW:158.18
  • Specification: USP|EP|BP
  • Purity:98%,99% or As customer requested
  • Color: Light orange powder.
  • Water Solubility:Insoluble in water.
  • Product Categories: Organic acids;Cephalosporins;Thiazoles;Nitrogen cyclic compounds;Heterocyclic Compounds
  • Test method: HPLC

2-Amino-4-thiazole acetic acid is a building block used in the synthesis of different active pharmaceutical products, specifically in the process of manufacture of Cefotiam. 2-Amino-4-thiazole acetic acid is incorporated in Cefotiam as amide, but it could be re-obtained by hydrolysis, and so it becomes an obvious potential degradation impurity. 

Following the possibility to have this compound as by-process or degradation impurity, above the identification thresholds outlined by ICHQ3A (1), as foreseen by ICH M7 (2), it needs to be evaluated for its potential genotoxicity.

2 2 aminothiazol 4 yl acetic acid Basic information  
Product Name: 2-Aminothiazol-4-acetic acid
Synonyms: (2-AMino-1,3-thiazol-4-yl)acetic acid;2-AMino-4-thiazolacetic acid;Ceftibuten Related Impurity 2;2-(2-amino-1,3-thiazol-4-yl)ethanoic acid;Ethyl-2-(2-aminothiazol-4-yl)-2-oxo-acetate(EAOA);2-Aminothiazol-4-acetic aCld;ATAH 2-(2-Aminothiazol-4-yl) acetic acid;2-(2-azaniumyl-1,3-thiazol-4-yl)acetate
CAS: 29676-71-9
MW: 158.18
EINECS: 249-769-6
Product Categories: Building Blocks;Heterocyclic Building Blocks;Organic acids; Cephalosporins;Sulphur Derivatives;Heterocyclic Compounds

2 2 aminothiazol 4 yl acetic acid Chemical Structure

2-Aminothiazol-4-acetic acid            

2 Aminothiazol 4 acetic acid Chemical Properties    
Melting point  130 °C (dec.)(lit.)
Boiling point  399.0±17.0 °C(Predicted)
density  1.367 (estimate)
refractive index  1.6430 (estimate)
storage temp.  Refrigerator
pka 3.20±0.10(Predicted)
form  solid
Water Solubility  6.5 g/L (20 ºC)
BRN  127415
2 Aminothiazol 4 acetic acid Usage And Synthesis    
Chemical Properties Almost white to light beige crystalline powder
General Description Light orange powder.
Air & Water Reactions Insoluble in water.
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