2-Aminothiazol-4-acetic Acid

Description

2-Amino-4-thiazole acetic acid is a building block used in the synthesis of different active pharmaceutical products, specifically in the process of manufacture of Cefotiam. 2-Amino-4-thiazole acetic acid is incorporated in Cefotiam as amide, but it could be re-obtained by hydrolysis, and so it becomes an obvious potential degradation impurity.

Following the possibility to have this compound as by-process or degradation impurity, above the identification thresholds outlined by ICHQ3A (1), as foreseen by ICH M7 (2), it needs to be evaluated for its potential genotoxicity.

2 2 aminothiazol 4 yl acetic acid Basic information

Product Name:	2-Aminothiazol-4-acetic acid
Synonyms:	(2-AMino-1,3-thiazol-4-yl)acetic acid;2-AMino-4-thiazolacetic acid;Ceftibuten Related Impurity 2;2-(2-amino-1,3-thiazol-4-yl)ethanoic acid;Ethyl-2-(2-aminothiazol-4-yl)-2-oxo-acetate(EAOA);2-Aminothiazol-4-acetic aCld;ATAH 2-(2-Aminothiazol-4-yl) acetic acid;2-(2-azaniumyl-1,3-thiazol-4-yl)acetate
CAS:	29676-71-9
MF:	C5H6N2O2S
MW:	158.18
EINECS:	249-769-6
Product Categories:	Building Blocks;Heterocyclic Building Blocks;Organic acids; Cephalosporins;Sulphur Derivatives;Heterocyclic Compounds

2 2 aminothiazol 4 yl acetic acid Chemical Structure

2-Aminothiazol-4-acetic acid

2 Aminothiazol 4 acetic acid Chemical Properties

Melting point	130 °C (dec.)(lit.)
Boiling point	399.0±17.0 °C(Predicted)
density	1.367 (estimate)
refractive index	1.6430 (estimate)
storage temp.	Refrigerator
pka	3.20±0.10(Predicted)
form	solid
Water Solubility	6.5 g/L (20 ºC)
BRN	127415

2 Aminothiazol 4 acetic acid Usage And Synthesis

Chemical Properties	Almost white to light beige crystalline powder
General Description	Light orange powder.
Air & Water Reactions	Insoluble in water.

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Main features and applications:

Intermediate compound: 2-Aminothiazol-4-acetic Acid is one of the key intermediates in the synthesis of various drugs. It is widely used in the preparation of antibiotics, antiviral drugs, antitumor drugs, and other bioactive molecules.
Chemical synthesis: ATA plays an important role in organic synthesis through its versatility. It can be used to construct biologically active compounds and as a starting material for the synthesis of a variety of compounds.
Drug research and development: This compound has potential application prospects in the field of drug research and development. Its structure and properties make it an important component in the design and development of new drugs.

Advantages and services:

High quality assurance: We provide high-purity 2-Aminothiazol-4-acetic Acid, which meets industry standards, and can provide customized services according to customer requirements.
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