2-Amino-4-thiazole acetic acid is a building block used in the synthesis of different active pharmaceutical products, specifically in the process of manufacture of Cefotiam. 2-Amino-4-thiazole acetic acid is incorporated in Cefotiam as amide, but it could be re-obtained by hydrolysis, and so it becomes an obvious potential degradation impurity.
Following the possibility to have this compound as by-process or degradation impurity, above the identification thresholds outlined by ICHQ3A (1), as foreseen by ICH M7 (2), it needs to be evaluated for its potential genotoxicity.
| Product Name: | 2-Aminothiazol-4-acetic acid |
| Synonyms: | (2-AMino-1,3-thiazol-4-yl)acetic acid;2-AMino-4-thiazolacetic acid;Ceftibuten Related Impurity 2;2-(2-amino-1,3-thiazol-4-yl)ethanoic acid;Ethyl-2-(2-aminothiazol-4-yl)-2-oxo-acetate(EAOA);2-Aminothiazol-4-acetic aCld;ATAH 2-(2-Aminothiazol-4-yl) acetic acid;2-(2-azaniumyl-1,3-thiazol-4-yl)acetate |
| CAS: | 29676-71-9 |
| MF: | C5H6N2O2S |
| MW: | 158.18 |
| EINECS: | 249-769-6 |
| Product Categories: | Building Blocks;Heterocyclic Building Blocks;Organic acids; Cephalosporins;Sulphur Derivatives;Heterocyclic Compounds |
| Melting point | 130 °C (dec.)(lit.) |
| Boiling point | 399.0±17.0 °C(Predicted) |
| density | 1.367 (estimate) |
| refractive index | 1.6430 (estimate) |
| storage temp. | Refrigerator |
| pka | 3.20±0.10(Predicted) |
| form | solid |
| Water Solubility | 6.5 g/L (20 ºC) |
| BRN | 127415 |
| Chemical Properties | Almost white to light beige crystalline powder |
| General Description | Light orange powder. |
| Air & Water Reactions | Insoluble in water. |
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.
MSDS: MSDS available.
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
2-Amino-4-thiazole acetic acid is a building block used in the synthesis of different active pharmaceutical products, specifically in the process of manufacture of Cefotiam. 2-Amino-4-thiazole acetic acid is incorporated in Cefotiam as amide, but it could be re-obtained by hydrolysis, and so it becomes an obvious potential degradation impurity.
Following the possibility to have this compound as by-process or degradation impurity, above the identification thresholds outlined by ICHQ3A (1), as foreseen by ICH M7 (2), it needs to be evaluated for its potential genotoxicity.
| Product Name: | 2-Aminothiazol-4-acetic acid |
| Synonyms: | (2-AMino-1,3-thiazol-4-yl)acetic acid;2-AMino-4-thiazolacetic acid;Ceftibuten Related Impurity 2;2-(2-amino-1,3-thiazol-4-yl)ethanoic acid;Ethyl-2-(2-aminothiazol-4-yl)-2-oxo-acetate(EAOA);2-Aminothiazol-4-acetic aCld;ATAH 2-(2-Aminothiazol-4-yl) acetic acid;2-(2-azaniumyl-1,3-thiazol-4-yl)acetate |
| CAS: | 29676-71-9 |
| MF: | C5H6N2O2S |
| MW: | 158.18 |
| EINECS: | 249-769-6 |
| Product Categories: | Building Blocks;Heterocyclic Building Blocks;Organic acids; Cephalosporins;Sulphur Derivatives;Heterocyclic Compounds |
| Melting point | 130 °C (dec.)(lit.) |
| Boiling point | 399.0±17.0 °C(Predicted) |
| density | 1.367 (estimate) |
| refractive index | 1.6430 (estimate) |
| storage temp. | Refrigerator |
| pka | 3.20±0.10(Predicted) |
| form | solid |
| Water Solubility | 6.5 g/L (20 ºC) |
| BRN | 127415 |
| Chemical Properties | Almost white to light beige crystalline powder |
| General Description | Light orange powder. |
| Air & Water Reactions | Insoluble in water. |
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.
MSDS: MSDS available.
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
