| Product Name: | Amphotericin B |
| Synonyms: | FUNGIZONE;FUNGIZONE(R);ABELCET;AMBISOME;AMPHOTERCIN B;AMPHOTERICIN B;AMPHOTERICIN B SOLUBILIZED;AMPHOTERICIN B, SOLUBLE |
| CAS: | 1397-89-3 |
| MF: | C47H73NO17 |
| MW: | 924.08 |
| EINECS: | 215-742-2 |
| Product Categories: | Antibiotics; Antibacterial; Antimycobacterial; ABELCET; APIs; Miscellaneous Natural Products; Intermediates & Fine Chemicals |
| Mol File: | 1397-89-3.mol |
Amphotericin B is a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.
| Melting point | >170°C |
| alpha | D24 +333° (acidic DMF); -33.6° (0.1N methanolic HCl) |
| Boiling point | 804.34°C (rough estimate) |
| density | 1.34 |
| refractive index | 1.5280 (estimate) |
| storage temp. | 2-8°C |
| solubility | sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at −20?#x00b0;C. Stable at 37?#x00b0;C for 3 days. |
| pka | pKa ～5.7(DMF/H2O) (Uncertain) |
| form | powder |
| color | yellow |
| Water Solubility | <0.1 g/100 mL at 21 ºC |
| Sensitive | Moisture & Light Sensitive |
| Merck | 13,590 |
| BRN | 78342 |
| Stability: | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | APKFDSVGJQXUKY-INPOYWNPSA-N |
| CAS DataBase Reference | 1397-89-3(CAS DataBase Reference) |
| EPA Substance Registry System | Amphotericin B (1397-89-3) |
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
| Product Name: | Amphotericin B |
| Synonyms: | FUNGIZONE;FUNGIZONE(R);ABELCET;AMBISOME;AMPHOTERCIN B;AMPHOTERICIN B;AMPHOTERICIN B SOLUBILIZED;AMPHOTERICIN B, SOLUBLE |
| CAS: | 1397-89-3 |
| MF: | C47H73NO17 |
| MW: | 924.08 |
| EINECS: | 215-742-2 |
| Product Categories: | Antibiotics; Antibacterial; Antimycobacterial; ABELCET; APIs; Miscellaneous Natural Products; Intermediates & Fine Chemicals |
| Mol File: | 1397-89-3.mol |
Amphotericin B is a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.
| Melting point | >170°C |
| alpha | D24 +333° (acidic DMF); -33.6° (0.1N methanolic HCl) |
| Boiling point | 804.34°C (rough estimate) |
| density | 1.34 |
| refractive index | 1.5280 (estimate) |
| storage temp. | 2-8°C |
| solubility | sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at −20?#x00b0;C. Stable at 37?#x00b0;C for 3 days. |
| pka | pKa ～5.7(DMF/H2O) (Uncertain) |
| form | powder |
| color | yellow |
| Water Solubility | <0.1 g/100 mL at 21 ºC |
| Sensitive | Moisture & Light Sensitive |
| Merck | 13,590 |
| BRN | 78342 |
| Stability: | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | APKFDSVGJQXUKY-INPOYWNPSA-N |
| CAS DataBase Reference | 1397-89-3(CAS DataBase Reference) |
| EPA Substance Registry System | Amphotericin B (1397-89-3) |
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
