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Benzydamine Hydrochloride
Product name: Pharmaceuticals Grade Benzydamine hydrochloride
CAS No.: 132-69-4
MF: C19H23N3O.ClH
Purity: >98%
Chemical Properties: Off-White Solid
Description
What is Benzydamine Hydrochloride?
Benzydamine Hydrochloride is an indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties. Unlike other NSAIDs, benzydamine hydrochloride does not inhibit cyclooxygenases (COX) but stabilizes membranes, resulting in local anesthesia; inhibits the production of pro-inflammatory cytokines; inhibits the generation of reactive oxygen species by neutrophils; inhibits leukocyte aggregation and adhesion; and exhibits antimicrobial properties. (Source: NCI Thesaurus (NCIt)
Benzydamine Hydrochloride Product Description
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Product Name: |
Benzydamine hydrochloride |
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Synonyms: |
LABOTEST-BB LT00771795;BENZYDAMINE HCL;BENZYDAMINE HYDROCHLORIDE;1-BENZYL-3-[3-(DIMETHYLAMINO)-PROPOXY]-1H-INDAZOLE HYDROCHLORIDE;epirotin;imotryl;indolin;n,n-dimethyl-3-((1-(phenylmethyl)-1h-indazol-3-yl)oxy)-1-propanaminhydro |
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CAS: |
132-69-4 |
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MF: |
C19H23N3O.ClH |
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MW: |
345.87 |
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EINECS: |
205-076-0 |
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Product Categories: |
ROBINUL;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate |
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Mol File: |
132-69-4.mol |
BENZYDAMINE HCL Chemical Structure
Imotryl Chemical Properties
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Melting point |
147-153°C |
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storage temp. |
2-8°C |
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form |
neat |
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Water Solubility |
Soluble in water, ethanol, chloroform, n-butanol or DMSO /n |
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Merck |
14,1122 |
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InChIKey |
HNNIWKQLJSNAEQ-UHFFFAOYSA-N |
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CAS DataBase Reference |
132-69-4(CAS DataBase Reference) |
Indolin Manufacturing Process
To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120 ml of concentrated hydrochloric acid at 25°C was added concentrated solution of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in 1.5 L of water. To this solution under nitrogen was added 400 g of sodium bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The obtained solid product was dissolved in water and then to the solution was added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino) propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt.
Benzydamine Hydrochloride Side Effects
The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.
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