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Benzydamine Hydrochloride (132-69-4) C19H23N3O.ClH

Product name: Pharmaceuticals Grade Benzydamine hydrochloride
CAS No.: 132-69-4
MF: C19H23N3O.ClH
Purity: >98%
Chemical Properties: Off-White Solid
 
 
 
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Benzydamine Hydrochloride is an indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties. Unlike other NSAIDs, benzydamine hydrochloride does not inhibit cyclooxygenases (COX) but stabilizes membranes, resulting in local anesthesia; inhibits the production of pro-inflammatory cytokines; inhibits the generation of reactive oxygen species by neutrophils; inhibits leukocyte aggregation and adhesion; and exhibits antimicrobial properties.  (Source: NCI Thesaurus (NCIt)

Benzydamine Hydrochloride Product Description

 

Product Name:

Benzydamine hydrochloride

Synonyms:

LABOTEST-BB LT00771795;BENZYDAMINE HCL;BENZYDAMINE HYDROCHLORIDE;1-BENZYL-3-[3-(DIMETHYLAMINO)-PROPOXY]-1H-INDAZOLE HYDROCHLORIDE;epirotin;imotryl;indolin;n,n-dimethyl-3-((1-(phenylmethyl)-1h-indazol-3-yl)oxy)-1-propanaminhydro

CAS:

132-69-4

MF:

C19H23N3O.ClH

MW:

345.87

EINECS:

205-076-0

Product Categories:

ROBINUL;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate

Mol File:

132-69-4.mol

BENZYDAMINE HCL Chemical Structure


Benzydamine hydrochloride

    

Imotryl Chemical Properties

         

Melting point 

147-153°C

storage temp. 

2-8°C

form 

neat

Water Solubility 

Soluble in water, ethanol, chloroform, n-butanol or DMSO /n

Merck 

14,1122

InChIKey

HNNIWKQLJSNAEQ-UHFFFAOYSA-N

CAS DataBase Reference

132-69-4(CAS DataBase Reference)


Indolin Manufacturing Process


To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120 ml of concentrated hydrochloric acid at 25°C was added concentrated solution of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in 1.5 L of water. To this solution under nitrogen was added 400 g of sodium bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The obtained solid product was dissolved in water and then to the solution was added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino) propoxy)-1H-indazole 70%, M.P. 154-156°C.

In practice it is usually used as monohydrochloride salt.


Benzydamine Hydrochloride Side Effects


The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.

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