LAPPACONITINE HYDROBROMIDE

Description

LAPPACONITINE HYDROBROMIDE Introduction

Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias. IC50 value: Target: A natural product for anti-cardiac arrhythmias In vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence.

In vivo: The effect of Lappaconitine hydrobromide on aconitine–induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels, conducting ionic currents (I(Na), I(to), I(Ks), I(K1), I(CaT)), which are involved in the formation of different phases of the action potential. Lappaconitine hydrobromide was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day.

LAPPACONITINE HYDROBROMIDE Basic Information

Product Name:	LAPPACONITINE HYDROBROMIDE
Synonyms:	Lappaconitine Hydrobromide And Glucose Injection;Lappaconitine Hydrobromide 97792-45-5;Lappaconitine Hydrobromide, CP;LAPPACONITINE HBR;LAPPACONITINE HYDROBROMIDE;ALLAPININE;ALLAPININE HYDROBROMIDE;(1-alpha,14-alpha,16-beta)-monohydrobromide
CAS:	97792-45-5
MF:	C32H45BrN2O8
MW:	665.61
Product Categories:	Pyridines; Inhibitors; Miscellaneous Natural Products
Mol File:	97792-45-5.mol