Pramipexole

Description

What is Pramipexole?

Pramipexole is a drug used to treat the symptoms of Parkinson’s Disease (PD). It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson’s symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson’s Disease is one of the most common neurodegenerative disorders and causes a high level of disability in patients, leading to increased difficulty in performing activities of daily living due to symptoms that progress over time. The prevalence of Parkinson’s Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016. This increase may be attributed to an aging population along with other contributing factors. In addition to the above FDA approval for Parkinson’s Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS). RLS is a sleep-related disorder characterized by unpleasant sensations in the lower extremities, often accompanied by an uncontrollable urge to move the legs.(Source: DrugBank)

Basic introduction

Product Name:	Pramipexole
Synonyms:	Pramipexol; Pramipexolum; PRAMIPEXOLE HCl; Pramipexolum
CAS:	104632-26-0
MF:	C10H17N3S
MW:	211.33
EINECS:	600-593-1
Product Categories:	API; All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals

Chemical Structure

Pramipexole

Pramipexole Chemical Properties

Melting point	288-290°C
Boiling point	378.0±42.0 °C(Predicted)
density	1.17±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
pka	9.47±0.20(Predicted)

Pramipexole Uses

Pramipexole is a member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively. It has a role as an antiparkinson drug, a dopamine agonist, an antidyskinesia agent and a radical scavenger. It is a member of benzothiazoles and a diamine. It is a conjugate base of a pramipexole(2+).

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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