Brompheniramine Maleate

Description

Brompheniramine Hydrogen Maleate Introduction

Brompheniramine maleate is the maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. It has a role as an anti-allergic agent. It contains a brompheniramine.

Brompheniramine maleate is an allergy medicine that is utilized to treat wheezing, runny nose, and irritated or watery eyes brought about by sensitivities, roughage fever, and the normal virus.

Phenylephrine hcl brompheniramine maleate may likewise be utilized for purposes not recorded in this drug guide.

Veltane Basic information

Product Name:	Brompheniramine hydrogen maleate
Synonyms:	2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1); 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1); dimegan;dimetane; dimetanemaleate; RS-brompheniramine maleate; dimotane;g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate
CAS:	980-71-2
MF:	C20H23BrN2O4
MW:	435.31
EINECS:	213-562-9
Product Categories:	Amines; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File:	980-71-2.mol

Lodrane Chemical Structure

Brompheniramine hydrogen maleate

Dimetapp Allergy Chemical Properties

Melting point	134-135°C
Fp	9℃
storage temp.	Refrigerator
solubility	Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
form	neat
λmax	261nm(lit.)
Merck	14,1443
InChIKey	SRGKFVAASLQVBO-BTJKTKAUSA-N
CAS DataBase Reference	980-71-2(CAS DataBase Reference)
EPA Substance Registry System	2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2)

Brompheniramine Hydrogen Maleate Usage And Synthesis

Chemical Properties	White Solid
Uses	This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine.
Uses	Antihistaminic;H1 Antagonist
Definition	ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Manufacturing Process	Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol.
Therapeutic Function	Antihistaminic
General Description	Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine.
Side effects	The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction.