Brompheniramine maleate is the maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. It has a role as an anti-allergic agent. It contains a brompheniramine.
Brompheniramine maleate is an allergy medicine that is utilized to treat wheezing, runny nose, and irritated or watery eyes brought about by sensitivities, roughage fever, and the normal virus.
Phenylephrine hcl brompheniramine maleate may likewise be utilized for purposes not recorded in this drug guide.
| Product Name: | Brompheniramine hydrogen maleate |
| Synonyms: | 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1); 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1); dimegan;dimetane; dimetanemaleate; RS-brompheniramine maleate; dimotane;g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate |
| CAS: | 980-71-2 |
| MF: | C20H23BrN2O4 |
| MW: | 435.31 |
| EINECS: | 213-562-9 |
| Product Categories: | Amines; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals |
| Mol File: | 980-71-2.mol |
| Melting point | 134-135°C |
| Fp | 9℃ |
| storage temp. | Refrigerator |
| solubility | Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. |
| form | neat |
| λmax | 261nm(lit.) |
| Merck | 14,1443 |
| InChIKey | SRGKFVAASLQVBO-BTJKTKAUSA-N |
| CAS DataBase Reference | 980-71-2(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2) |
| Chemical Properties | White Solid |
| Uses | This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine. |
| Antihistaminic;H1 Antagonist | |
| Definition | ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. |
| Manufacturing Process | Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol. |
| Therapeutic Function | Antihistaminic |
| General Description | Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine. |
| Side effects | The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction. |
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
Brompheniramine maleate is the maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. It has a role as an anti-allergic agent. It contains a brompheniramine.
Brompheniramine maleate is an allergy medicine that is utilized to treat wheezing, runny nose, and irritated or watery eyes brought about by sensitivities, roughage fever, and the normal virus.
Phenylephrine hcl brompheniramine maleate may likewise be utilized for purposes not recorded in this drug guide.
| Product Name: | Brompheniramine hydrogen maleate |
| Synonyms: | 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate(1:1); 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1); dimegan;dimetane; dimetanemaleate; RS-brompheniramine maleate; dimotane;g-(4-bromophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate |
| CAS: | 980-71-2 |
| MF: | C20H23BrN2O4 |
| MW: | 435.31 |
| EINECS: | 213-562-9 |
| Product Categories: | Amines; Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals |
| Mol File: | 980-71-2.mol |
| Melting point | 134-135°C |
| Fp | 9℃ |
| storage temp. | Refrigerator |
| solubility | Soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride. |
| form | neat |
| λmax | 261nm(lit.) |
| Merck | 14,1443 |
| InChIKey | SRGKFVAASLQVBO-BTJKTKAUSA-N |
| CAS DataBase Reference | 980-71-2(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) (980-71-2) |
| Chemical Properties | White Solid |
| Uses | This drug is only available in combination with other medications: Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, Nasahist. The only difference between this agent and chlorpheniramine is the substitution of a bromine for a chlorine atom in brompheniramine. |
| Antihistaminic;H1 Antagonist | |
| Definition | ChEBI: The maleic acid salt of brompheniramine. A histamine H1 receptor antagonist, it is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. |
| Manufacturing Process | Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2- chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl- pyridyl acetonitrile. This intermediate is then hydrolyzed and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for 24 hours. The brompheniramine maleate may be made by reaction with maleic acid in ethanol followed by recrystallization from pentanol. |
| Therapeutic Function | Antihistaminic |
| General Description | Brompheniraminemaleate, (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate (Dimetane), differs fromchlorpheniramine by the substitution of a bromine atom forthe chlorine atom. Its actions and uses are like those of chlorpheniramine.It has a half-life of 25 hours, which is almosttwice that of chlorpheniramine. |
| Side effects | The side effects of this medication are similar to other classes of sedative antihistamines. Some medications include parabens. Patients sensitive to parabens may develop a sensitivity reaction. |
MSDS: MSDS available
COA: COA can be available if you send us inquiry.
Email us at: info@maxmedchem.com for more details.
