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Diphenhydramine Hydrochloride

  • Chemical Name: Diphenhydramine Hydrochloride
  • CAS No.: 147-24-0
  • MF:C17H22ClNO
  • MW: 291.82
  • Specification: USP|EP|BP
  • Purity:99% or As customer requested
  • Color: White or almost white, crystalline powder.
  • Categories: Pharmaceutical intermediates;Anilines, Aromatic Amines and Nitro Compounds;API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals
  • Solubility:Water soluble. Aqueous solutions are acidic.
  • Test method: HPLC


Diphenhydramine Hydrochloride Description

Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.

The molecular formula is C17H21NO·HCl and the structural formula is as follows:

Diphenhydramine Hydrochloride1

Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride high per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.

Diphenhydramine Hcl Basic information  

Product Name: Diphenhydramine Hydrochloride
Synonyms: 2-(diphenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride;2-(diphenylmethoxy)-n,n-dimethyl-ethylaminhydrochloride;Actifed;alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride;alpha-hydroxydiphenylmethane-beta-dimethylaminoethyletherhydrochloride;Ambenyl;BAX;Benacine
CAS: 147-24-0
MF: C17H22ClNO
MW: 291.82
EINECS: 205-687-2
Product Categories: On the central nervous activity inhibition of sedative hypnotic effect; API; Histamine receptor; BENADRIL; Other APIs; Pharmaceutical intermediates; Anilines, Aromatic Amines and Nitro Compounds; API intermediates; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File: 147-24-0.mol

Dimedrol Chemical Structure

Diphenhydramine Hydrochloride            

Cathejell Chemical Properties


Melting point  168-172 °C
Boiling point  163-167 °C(Press: 3 Torr)
density  1.0489 (rough estimate)
refractive index  1.5800 (estimate)
Fp  9℃
storage temp.  Desiccate at RT
solubility  Very soluble in water, freely soluble in alcohol.
form  Crystalline Powder or Adhering Crystals
color  White
PH pH(100g/L, 25℃) 4.0~5.5
Water Solubility  1000 g/L
Sensitive  Light Sensitive
Merck  14,3309
Stability: Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.
CAS DataBase Reference 147-24-0(CAS DataBase Reference)
NIST Chemistry Reference diphenhydramine hydrochloride(147-24-0)
EPA Substance Registry System Diphenhydramine hydrochloride (147-24-0)

Diphenhydramine Hydrochloride Usage And Synthesis

Indications and Usage Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.

  1. antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.

  2. Motion Sickness: For active treatment of motion sickness.

  3. Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.

  1. Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.

  2. Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.

  3. Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.

  4. Antihistamines are also contraindicated in the following conditions: Hyper sensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.

Chemical Properties White or almost white, crystalline powder.

Diphenhydramine hydrochloride is used as an antihistamine and for its antieholinergie (drying) and sedative effects; for allergic conjunctivitis due to foods; for mild, uncomplicated allergic skin manifestations of urticaria and angioedema; for amelioration of allergic reactions to blood or plasma; for dermatographism; in therapy for anaphylaetie reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled; for active and prophylactie treatment of motion sickness; for parkinsonism; an antiemetic; has local anesthetic properties; in preparations for the relief of cough; in the prevention and treatment of radiation sickness, nausea and vomiting; for treatment of allergie cheilitis and stomatitis.
Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.
antihistamine, sedative, treatment of allergic
A histamine H1-receptor antagonist.
H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic
Brand name Benadryl (Parke-Davis).
Therapeutic Function Antihistaminic
General Description White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.
Air & Water Reactions Water soluble. Aqueous solutions are acidic.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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