- Chemical Name: Diphenhydramine Hydrochloride
- CAS No.: 147-24-0
- MW: 291.82
- Specification: USP|EP|BP
- Purity:99% or As customer requested
- Color: White or almost white, crystalline powder.
- Categories: Pharmaceutical intermediates;Anilines, Aromatic Amines and Nitro Compounds;API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals
- Solubility：Water soluble. Aqueous solutions are acidic.
- Test method: HPLC
Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
The molecular formula is C17H21NO·HCl and the structural formula is as follows:
Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride high per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.
|Product Name:||Diphenhydramine Hydrochloride|
|Synonyms:||2-(diphenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride;2-(diphenylmethoxy)-n,n-dimethyl-ethylaminhydrochloride;Actifed;alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride;alpha-hydroxydiphenylmethane-beta-dimethylaminoethyletherhydrochloride;Ambenyl;BAX;Benacine|
|Product Categories:||On the central nervous activity inhibition of sedative hypnotic effect; API; Histamine receptor; BENADRIL; Other APIs; Pharmaceutical intermediates; Anilines, Aromatic Amines and Nitro Compounds; API intermediates; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals|
|Melting point||168-172 °C|
|Boiling point||163-167 °C(Press: 3 Torr)|
|density||1.0489 (rough estimate)|
|refractive index||1.5800 (estimate)|
|storage temp.||Desiccate at RT|
|solubility||Very soluble in water, freely soluble in alcohol.|
|form||Crystalline Powder or Adhering Crystals|
|PH||pH(100g/L, 25℃) 4.0～5.5|
|Water Solubility||1000 g/L|
|Stability:||Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.|
|CAS DataBase Reference||147-24-0(CAS DataBase Reference)|
|NIST Chemistry Reference||diphenhydramine hydrochloride(147-24-0)|
|EPA Substance Registry System||Diphenhydramine hydrochloride (147-24-0)|
|Indications and Usage||Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.
|Chemical Properties||White or almost white, crystalline powder.|
|Uses||Diphenhydramine hydrochloride is used as an antihistamine and for its antieholinergie (drying) and sedative effects; for allergic conjunctivitis due to foods; for mild, uncomplicated allergic skin manifestations of urticaria and angioedema; for amelioration of allergic reactions to blood or plasma; for dermatographism; in therapy for anaphylaetie reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled; for active and prophylactie treatment of motion sickness; for parkinsonism; an antiemetic; has local anesthetic properties; in preparations for the relief of cough; in the prevention and treatment of radiation sickness, nausea and vomiting; for treatment of allergie cheilitis and stomatitis.|
|Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.|
|antihistamine, sedative, treatment of allergic|
|A histamine H1-receptor antagonist.|
|H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic|
|Brand name||Benadryl (Parke-Davis).|
|General Description||White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.|
|Air & Water Reactions||Water soluble. Aqueous solutions are acidic.|
MSDS: MSDS available
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