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Chemical Name: Clarithromycin
CAS No.: 81103-11-9
MF: C38H69NO13
Purity: ≥98% or according to customer requested
Color: colorless to faint yellow
Product Categories: Pharmaceutical raw materials; APIs; Antibiotics; Macrolides
Test method: HPLC




What is Clarithromycin?

Clarithromycin is a semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. 

It is used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis. It has a role as an antibacterial drug, a protein synthesis inhibitor, an environmental contaminant and a xenobiotic.

Basic Information


Product Name: Clarithromycin
Synonyms: Clarithromycine; Clarithromycinum
CAS: 81103-11-9
MF: C38H69NO13
MW: 747.95
EINECS: 1806241-263-5
Product Categories: Pharmaceutical raw materials; APIs; Antibiotics; Macrolides
Chemical Structure


Chemical Properties


Melting point 217-220°C
alpha D24 -90.4° (c = 1 in CHCl3)
Boiling point 86℃
density 1.1334 (rough estimate)
refractive index -92 ° (C=1, CHCl3)
Fp >110°(230°F)
storage temp. -20°C
solubility Soluble in DMSO
pka pKa 8.99(H2O t=25.0 I=0.167) (Uncertain)
form powder
color colorless to faint yellow
Water Solubility 99.48mg/L(20 ºC)
Stability: Store in Freezer
Clarithromycin Uses

Clarithromycin is a macrolide antibiotic active against a broad range of Gram positive bacteria. Clarithromycin was designed to enhance acid stability and improve oral bioavailability compared with erythromycin which is highly unstable to acidic conditions, undergoing a series of internal ketalisations between the 9-keto moiety and alcohols at C6 and C11. Omura and colleagues found that protection of the labile 6-OH group by methylation provided a simple but elegant solution.

Clarithromycin effects

1. It can be used to treat pharyngitis and tonsillitis caused by Streptococcus pyogenes.

2. It can be used to treat acute otitis media, sinusitis, acute bronchitis, acute attack of chronic bronchitis and pneumonia caused by sensitive bacteria.

3. It can be used to treat skin and soft tissue infections caused by sensitive bacteria.

4. It can be used to treat Mycoplasma pneumoniae pneumonia, urethritis caused by Chlamydia trachomatis and non-specific urethritis (cervicitis), etc.

5. It can be used to treat Legionnaires’ disease (legionella infection).

6. Clarithromycin can also be used in combination with other drugs to treat Mycobacterium avium infection and Helicobacter pylori infection.

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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