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TRAMADOL HYDROCHLORIDE (36282-47-0) C16H26ClNO2

  • Chemical Name: Tramadol hydrochloride
  • CAS No.: 22204-88-2
  • MF: C16H26ClNO2
  • MW:299.84
  • Specification: USP|EP|BP
  • Purity: 97% or As customer requested
  • Chemical Properties:White Cyrstalline Solid
  • Categories: Intermediates & Fine Chemicals;Pharmaceuticals
  • Test method: HPLC
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TRAMADOL HYDROCHLORIDE Basic Information        

Product Name: Tramadol hydrochloride
Synonyms: AURORA KA-863; (+/-)-CIS-2-(DIMETHYLAMINOMETHYL)-1-(3-METHOXYPHENYL)CYCLOHEXANOL HYDROCHLORIDE; CIS-TRAMADOL HYDROCHLORIDE; O-DESMETHYL-CIS-TRAMADOL HCL; TRAMADOL HCL; TRAMODOL HCL; TRAMADOL HYDROCHLORIDE; 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-1-cyclohexanol hydrochloride
CAS: 22204-88-2
MF: C16H26ClNO2
MW: 299.84
EINECS: 220-831-4
Product Categories: Opioid receptor and opioid-like receptor; Intermediates & Fine Chemicals; Pharmaceuticals
Mol File: 22204-88-2.mol

Tramadol Hcl Chemical Structure

Tramadol hydrochloride               

Tramadol Hydrochloride Tablets Chemical Properties

           
Melting point  171°C
Fp  9℃
storage temp.  2-8°C
CAS DataBase Reference 22204-88-2(CAS DataBase Reference)

TRAMADOL HYDROCHLORIDE Usage And Synthesis

Chemical Properties White Cyrstalline Solid
Uses An Analgesic
Manufacturing Process 5 g of magnesium turnings are treated while stirring with a mixture of 37.4 g of m-bromoanisole and 160 ml of absolute tetrahydrofuran at such a rate that the reaction mixture boils gently because of the heat produced by the immediately starting reaction. Thereafter, the reaction mixture is boiled under reflux while stirring until all the magnesium dissolves. The reaction mixture is cooled to 0°C to -10°C and then a mixture of 23.25 g of 2- dimethylaminomethylcyclohexanone and 45 ml of absolute tetrahydrofuran is added dropwise.
The resulting mixture is stirred for 4 hours at room temperature and then poured, while stirring slowly, into a mixture of 25 g of ammonium chloride, 50 ml of water and 50 g of ice. The layers are separated and the aqueous layer is extracted twice with 50 ml portions of ether. The organic layers are combined, dried with sodium sulfate and evaporated. The residue is distilled, and 1-(m_x0002_methoxyphenyl)-2-dimethylaminomethyl-cyclohexanol-(1), boiling point at 0.6 mm Hg 138°C to 140°C, is obtained in a yield of 78.6% of theoretical. The hydrochloride obtained from the product, e.g., by dissolving in ether and treating with dry hydrogen chloride, melts at 168°C to 175°C. By recrystallization from moist dioxan this hydrochloride is separated into isomers melting at 162°C to 163°C and 175°C to 177°C, respectively.
Therapeutic Function Analgesic

Tramadol hydrochloride Preparation Products And Raw materials

Raw materials

Hydrochloric acid-->Tetrahydrofuran-->Acetone-->Ammonium chloride-->1,4-Dioxane-->Dimethylamine-->Iodine-->Paraformaldehyde-->Cyclohexane-->Cyclohexanone-->3-Bromoanisole-->2-Piperazinecarboxylic acid methyl ester-->2-[(dimethylamino)methyl]cyclohexan-1-one-->Magnesium

Storage: 

Please store the product under the recommended conditions in the Certificate of Analysis.

Biological activity:

3,4-Dimethoxybenzamide, amide, is isolated from the solid culture of Streptoverticillium morookaense. 3,4-Dimethoxybenzamide can be used as the starting material to preparation Itopride hydrochloride[1][2].       


MSDS: MSDS available

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