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ERYTHROMYCIN LACTOBIONATE

  • Chemical Name:ERYTHROMYCIN LACTOBIONATE (200 MG)
  • CAS No.:3847-29-8
  • MF: C37H67NO13.C12H22O12
  • MW:1092.22
  • Specification: USP|EP|BP
  • Purity: 98%-99% or As customer requested
  • Appearance: White or slightly yellow hygroscopic, powder.
  • Water Solubility:Soluble in water, freely soluble in anhydrous ethanol and in methanol, very slightly soluble in acetone and in methylene chloride.
  • Product Categories: API;Peptide Synthesis/Antibiotics
  • Test method: HPLC
Category:

Description

Erythrocin Lactobionate (Sterile Erythromycin Lactobionate, USP), is a soluble salt of erythromycin suitable for intravenous administration. Erythrocin Lactobionate powder is available as a sterile, lyophilized powder in vials containing the equivalent of 500 mg or 1 g of erythromycin activity.

ERYTHROMYCIN LACTOBIONATE 200 MG Basic information   

Product Name: ERYTHROMYCIN LACTOBIONATE (200 MG)
Synonyms: ERYTHROMYCIN LACTOBIONATE USP(CRM STANDARD); Erythromycin, Lactobionate Salt-N,N-dimethyl-13C2; D-Gluconic acid, 4-O-β-D-galactopyranosyl-, compd. with erythromycin (1:1) (9CI); Erythrocin lactobionate; Erythromycin, 4-O-β-D-galactopyranosyl-D-gluconate (salt); Erythromycin, compd. with lactobionic acid (7CI); Erythromycin, lactobionate (1:1) (salt); Lactobionic acid, compd. with erythromycin (1:1) (8CI)
CAS: 3847-29-8
MF: C37H67NO13.C12H22O12
MW: 1092.22
EINECS: 223-348-7
Product Categories: API; Peptide Synthesis/Antibiotics
Mol File: 3847-29-8.mol

Erythromycin lactobionate Chemical Structure

ERYTHROMYCIN LACTOBIONATE (200 MG)            

ERYTHROMYCIN LACTOBIONATE USP Chemical Properties

           

Melting point  145-150°
density  0.9083 (rough estimate)
refractive index  1.5300 (estimate)
solubility  Soluble in water, freely soluble in anhydrous ethanol and in methanol, very slightly soluble in acetone and in methylene chloride.
Water Solubility  >20g/L(21 ºC)

ERYTHROMYCIN LACTOBIONATE 200 MG Usage And Synthesis

Chemical Properties White or slightly yellow hygroscopic, powder.
Uses Macrolide antibacterial.
Manufacturing Process A solution of erythromycin free base is prepared by dissolving 8.0 grams of erythromycin in 25 cc of acetone. 4.0 grams of lactobiono-delta-lactone is dissolved in 25 cc of water. The free lactobionic acid is formed in this solution and it has the molecular formula C12H22O12. The two solutions are mixed and evaporated to a gummy residue. This residue is dissolved in 60 cc of water and the solution is frozen and dried in vacuum by lyophilization. The dried residue of erythromycin lactobionate is a white amorphous powder and weighs 11.7 grams. The reaction product has an activity against B. subtilis of 420units per milligram. Its solubility in water is about 200 mg/cc and the melting point of the white powdery reaction product is 145° to 150°C.
Therapeutic Function Antibacterial
General Description Erythromycin lactobionate is a water-soluble salt preparedby reacting erythromycin base with lactobiono-σ-lactone. Itoccurs as an amorphous powder that is freely soluble inwater and alcohol and slightly soluble in ether. It is intended,after reconstitution in sterile water, for intravenousadministration to achieve high plasma levels in the treatmentof serious infections.

MSDS: MSDS available

COA: COA can be available if you send us inquiry.

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