How much do you know about chlorogenic acid?

What is Chlorogenic acid?

The chemical name is 3-caffeoylquinic acid, and molecular formula is C16H18O9 with the molecular weight 354.30.

Chlorogenic acid has pharmacological effects such as antibacterial, anti-inflammatory, detoxification, choleretic, antihypertensive, increasing white blood cells, significantly increasing gastrointestinal motility and promoting gastric juice secretion, and has strong inhibition on Escherichia coli, Staphylococcus aureus, pneumococcus and viruses Effect: It has obvious curative effect on acute throat inflammation and skin disease, and is clinically used for the treatment of acute bacterial infection and leukopenia caused by radiotherapy and chemotherapy. It has a good hemostatic effect on menorrhagia and functional uterine bleeding.

What is the pharmacological effects of Chlorogenic acid?

(1) Antihypertensive effect:

It has been confirmed by clinical trials for many years that chlorogenic acid has obvious antihypertensive effect, and the curative effect is stable, non-toxic and free of side effects. University of Wisconsin (Charles J Sih, et al. Separation and synthesis of pinoresinol diglucoside moides olive J Am Chem Soc 1976, 98(17): 5412 and other studies found that the active ingredient of green blood pressure lowering is pinoresinol diglucoside, peach leaves Bucoin, chlorogenic acid, and Eucommia chlorogenic acid polysaccharides.

(2) Anti-tumor effect:

Modern pharmacological experiments have proved that chlorogenic acid has anti-cancer and anti-tumor effects. Japanese scholars have studied the antimutagenicity of chlorogenic acid and found that this effect is related to anti-mutagenicity such as chlorogenic acid. It is related to the original components, revealing the important significance of chlorogenic acid in tumor prevention.

(3) Invigorating the kidney and enhancing immunity:

Experiments have shown that chlorogenic acid can stimulate the pituitary-adrenal cortex system and enhance the function of the adrenal cortex. Studies have found that chlorogenic acid can not only initiate the phagocytic activity of the monocyte-macrophage system and the peritoneal macrophage system, enhance the body’s non-specific immune function, but also inhibit delayed-type hypersensitivity reactions.

(4) Antioxidant, anti-aging, anti-musculoskeletal aging:

Chlorogenic acid contains a special ingredient that can promote the synthesis and decomposition of collagen in the skin, bones and muscles of the human body, and has the functions of promoting metabolism and preventing decline. To prevent the skeletal and muscle decline of astronauts caused by weightlessness in space, it was found that Eucommia chlorogenic acid has obvious anti-free radical effects both in vivo and in vitro.

(5) Antibacterial and antiviral:

Chlorogenic acid has strong antibacterial and anti-inflammatory effects, aucubin and its polymers have obvious antibacterial effects, and aucubin has both gram-negative and positive bacteria. inhibition. Acupuncture has antibacterial and diuretic effects, and can promote wound healing; acupuncture and glucoside can also have obvious antiviral effects after pre-culture, but it does not have antiviral functions by itself. Japan’s Aichi Medical University Institute of Advanced Medicine has confirmed that the alkaline substance extracted from it has the function of resisting viruses that destroy the human immune system, and this substance may be used for the prevention and treatment of AIDS.

(6) Other effects:

Diuretic, choleretic, hypolipidemic, and miscarriage protection.

Where could you find best Chlorogenic acid?

Natural Chlorogenic acid is a substance extracted from plants, derived from the leaves of the Eucommia family. Chlorogenic acid has important clinical applications and is an effective antibacterial and antiviral ingredient. Chlorogenic acid can be inactivated by proteins in the body and is available in a variety of formulations, including oral and injectable drugs. According to the results of related experiments, chlorogenic acid can stimulate central nervous system excitability and promote intestinal peristalsis. Chlorogenic acid belongs to the phenylpropanoid compound, which is formed in plants through aerobic respiration.

Maxmedchem could offer the Chlorogenic acid extracted from honeysuckle, coffee beans, sunflower, chrysanthemum and cocoa tree, and these are the most common sources of Chlorogenic acid.

Synthetic chlorogenic acid could also be offered from Maxmedchem.And the method for synthesizing chlorogenic acid and its derivatives comprises the following steps: comprising a phenylallylic acid compound (II) and a geminal dioxyidene-protected quinic acid compound (III) under stirring conditions in a condensing agent dicyclohexylcarbodiimide. Under the catalysis of amines and their analogs and organic bases, in an organic solvent, at a temperature of 0 to 100 ° C and a reaction time of 1 to 72 hours, and then in a diluted acid solution, at a temperature of 0 to 100 ° C and a reaction time of 1 to 72 hours. 1 to 72 hours for hydrolysis to obtain.

Welcome to send an inquiry about our chlorogenic acid at: info@maxmedchem.com