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Hydroxyproline (51-35-4) C5H9NO3

  • Chemical Name: L-Hydroxyproline
  • CAS No.:51-35-4
  • MF: C5H9NO3
  • MW:131.13
  • Purity:>98% or As customer requested
  • Color: White
  • Product Categories: Amino Acids; Biochemistry; Nutritional Supplements; Pharmaceuticals
  • Test method: HPLC

What is Hydroxyproline?

Hydroxyproline is a nonessential amino acid derivative formed during post-translational protein modification through hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase which requires vitamin C as a co-factor. Hydroxyproline is a major component of the protein collagen and plays a key role in the stability of the collagen triple helix. It can be used as an indicator to determine the amount of collagen. Increased hydroxyproline levels in the urine and/or serum are normally associated with degradation of connective tissue. Vitamin C deficiency decreases the conversion of proline to hydroxyproline, which leads to reduced collagen stability. (Source: NCI Thesaurus (NCIt))

Basic information
Product Name: L-Hydroxyproline
Synonyms: L-Hydroxyproline; trans-4-Hydroxyproline; Hypro; 4-hydroxyproline
CAS: 51-35-4
MW: 131.13
EINECS: 200-091-9
Product Categories: Amino Acids; Biochemistry; PHARMACEUTICALS; Biochemistry; Nutritional Supplements;
Chemical Structure


Chemical Properties  
Melting point  273 °C (dec.)(lit.)
alpha  -75.5 º (c=5, H2O)
Boiling point  242.42°C (rough estimate)
density  1.3121 (rough estimate)
vapor density  4.5 (vs air)
refractive index  -75.5 ° (C=4, H2O)
storage temp.  Store below +30°C.
solubility  H2O: 50 mg/mL
form  Crystals or Crystalline Powder
pka 1.82, 9.66(at 25℃)
color  White
PH 5.5-6.5 (50g/l, H2O, 20℃)
Odor Odorless
optical activity [α]25/D 75.6°, c = 1 in H2O
Water Solubility  357.8 g/L (20 º C)
Merck  14,4840
BRN  471933
Usage And Synthesis
Description A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.
Chemical Properties White crystalline powder

Hydroxyproline Uses

Hydroxyproline is a non-essential amino acid separated from another amino acid called proline. It is produced by the interaction of proline and vitamin C ascorbic acid. This process produces hydroxyl groups bound to hydrogen and oxygen molecules, which are connected to the carbon molecules of proline and converted into hydroxyproline.

This amino acid was first separated from the gel in 1902. It is one of the 22 amino acids required to form human protein and is also part of the standard human genetic code. Hydroxyproline is produced in the gastrointestinal tract.

Without vitamin C, it is impossible to produce hydroxyproline. Without it, serious problems will arise, because the body cannot produce collagen(the most important protein structure). Both proline and hydroxyproline are important for the formation of this key substance, and the lack of either will cause serious instability of collagen in the body.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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