Lincomycin Hydrochloride

Description

Lincomycin Hydrochloride Anhydrous is the anhydrous hydrochloride salt form of lincomycin, a lincosamide antibiotic originally identified in actinomycete Streptomyces lincolnensis with activity against gram-positive cocci and anaerobic bacteria.

Lincomycin hydrochloride appears as a white crystalline powder at room temperature with slight odor or special smell and bitter taste. It is soluble in water and methanol. Feed often applied its hydrochloride salt form. The drug is the product during the growth of the population of the Streptomyces genus (Streptomyces lincolnensis), as a kind of lincosamides alkaline antibiotics.(Source: Chemicalbook)

Lincomycin hydrochloride Basic information

Product Name:	Lincomycin hydrochloride
Synonyms:	METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;LINCOMYCIN HCL;LINCOMYCIN HYDROCHLORIDE;LINCOCIN HYDROCHLORIDE;lincomycin standard solution;ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;U-10149A;N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE
CAS:	859-18-7
MF:	C18H35ClN2O6S
MW:	443
EINECS:	212-726-7
Product Categories:	Peptide Synthesis/Antibiotics; Carbohydrates & Derivatives; Antibiotic Explorer; Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; Lincocin; antibiotic; API

Lincomycin hydrochloride Chemical Structure

Lincomycin hydrochloride

Lincomycin hcl monohydrate Chemical Properties

Melting point	156-158C
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
form	solid
color	white to white with yellow cast
Water Solubility	Soluble in water.
BRN	4171650
InChIKey	POUMFISTNHIPTI-BOMBIWCESA-N
EPA Substance Registry System	D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1) (859-18-7)

Lincomycin hcl monohydrate Usage And Synthesis

Chemical Properties	Crystalline
Uses	An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
	Antibacterial;Ribosomal protein synthesis inhibitor
	Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.