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Naftifine(65472-88-0)21H21N

  • Chemical Name: Naftifine
  • CAS No.:65472-88-0
  • MF: C21H21N
  • MW:287.4
  • Purity:≥98% or according to customer requested
  • Product Categories:Antifungal Drugs; Synthetic Anti-infective Drugs; APIs
  • Test method: HPLC
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What is Naftifine?

Naftifine is a tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor and a sterol biosynthesis inhibitor. It is a member of naphthalenes, a tertiary amine and an allylamine antifungal drug. (Source: ChEBI)

Introduction
          
Product Name: Naftifine
Synonyms: Naftifinum; Naftifin; Naftifina; Naftifine HCL
CAS: 65472-88-0
MF: C21H21N
MW: 287.4
Product Categories:

Antifungal Drugs; Synthetic Anti-infective Drugs; APIs; Pharmaceuticals
Chemical Structure

Naftifine            

Chemical Properties
         
Melting point  177 °C
Boiling point  bp0.015 torr 162-167°
density  1.082±0.06 g/cm3(Predicted)
pka 7.99±0.50(Predicted)
Merck  6355
Naftifine Uses And Synthesis  
Therapeutic Function Antifungal
Pharmaceutical Applications A topical antifungal used as a 1% cream for the treatment of dermatophytoses, including tinea pedis, tinea corporis and tinea cruris.
Clinical Use Naftifine was the first allyl amine to be discovered and marketed. It is subject to extensive first-pass metabolism to be orally active and, consequently, is only available in topical preparations. The widest use of naftifine is against various tinea infections of the skin.
Technical Support & Resources
Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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