- Chemical Name: Natamycin
- CAS No.: 7681-93-8
- MF: C33H47NO13
- MW: 665.73
- Purity: >98% or As customer requested
- Color: white or yellowish powder
- Solubility: 0.41g/L(21 ºC)
- Product Categories: Food & Feed ADDITIVES; Intermediates & Fine Chemicals; Pharmaceuticals; antibiotic; APIs
- Test method: HPLC
Natamycin is a polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. This leads to a leakage and loss of essential cellular constituents. Following ocular application, natamycin is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect. (Source: NCI Thesaurus (NCIt))
|Melting point||2000C (dec)|
|alpha||D20 +278° (c = 1 in CH3COOH)|
|density||1.0 g/mL at 20 °C(lit.)|
|refractive index||1.5960 (estimate)|
|storage temp.||Keep in dark place,Inert atmosphere,2-8°C|
|solubility||Soluble in DMSO|
|pka||pKa 4.6(50% aq. MeOEtOH) (Uncertain);8.35 (Uncertain)|
|Water Solubility||0.41g/L(21 ºC)|
Natamycin is used to treat fungal infections, including Candida, Aspergillus, Fusarium, etc. It is also used as eye drops or oral medicine. In these applications, the human body absorbs less Natamycin. When taken orally, it is basically not absorbed from the gastrointestinal tract, which makes it unsuitable as a systemic infectious drug. Natamycin is also used in eye drops. Its 5% natamycin content is suitable for the treatment of fungal blepharitis, conjunctivitis and keratitis caused by microorganisms, including Fusarium solani keratitis.
|Chemical Properties||White to Off-White Solid|
|Uses||Natamycin (l), from Streptomyces nataIensis and Streptomyces chat tanoogensis, is used for the control of diseases of bulbs.|
|Polyene antifungal antibiotic|
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