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Nifedipine Powder(21829-25-4)C17H18N2O6

  • Chemical Name: Nifedipine
  • CAS No.: 21829-25-4
  • MF: C17H18N2O6
  • MW: 346.33
  • Purity:≥98% or according to customer requested
  • Color:yellow
  • Product Categories: APIs;Intermediates & Fine Chemicals;Circulatory system drugs;Angina Pectoris Drugs
  • Test method: HPLC

What is Nifedipine?

Nifedipine is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

It is also a first generation calcium channel blocker used to treat hypertension and angina pectoris. Nifedipine therapy is associated with a low rate of serum enzyme elevations and has been linked to several instances of clinically apparent acute liver injury.

Basic information
Product Name: Nifedipine
Synonyms: Nifedipino; Nifedipinum
CAS: 21829-25-4
MF: C17H18N2O6
MW: 346.33
EINECS: 244-598-3
Product Categories: Pharmaceutical raw materials;APIs;Intermediates & Fine Chemicals;Circulatory system drugs;Angina Pectoris Drugs
Chemical Structure


Chemical Properties
Melting point 171-175 °C
Boiling point 481.08°C (rough estimate)
density 1.2109 (rough estimate)
refractive index 1.5486 (estimate)
storage temp. 2-8°C
solubility DMSO: soluble
pka pKa -0.9/>13(DMF,t undefined) (Uncertain)
form powder
color yellow
Water Solubility <0.1 g/100 mL at 19.5 ºC
Nifedipine Uses

It is used for the prevention and treatment of angina pectoris,with no adverse effects on respiratory function, its efficacy is best particularly for angina pectoris coronary spasm and obstructive airway disease with angina , its efficacy is superior to β-blockers.It is also applied to all types of high blood pressure, including severe and resistant hypertension. Treatment of refractory congestive heart failure may be taking this long. It is also used for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcers, urinary tract obstruction, exercise-induced asthma, achalasia.

Nifedipine Side Effects

Nifedipine has a high frequency of adverse reactions, but it is easy to tolerate, and is lighter with the decrease of the dose. Common adverse reactions are dizziness and headache, followed by fever, red face, foot edema and fluid retention, etc. These are actually widespread vasodilation effects. Adverse reactions generally appear 1.2 weeks after the medication, and then gradually subside. Generally, the medication does not need to be stopped after the side effects occur.

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