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Chemical Name: L-Proline
CAS No.: 147-85-3
Purity: 99% or according to customer requirements
Product Categories: Amino Acids;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Food & Feed ADDITIVES;
Test method: HPLC

What is Proline?

Proline is a cyclic, nonessential amino acid (actually, an imino acid) in humans (synthesized from glutamic acid and other amino acids), Proline is a constituent of many proteins. Found in high concentrations in collagen, proline constitutes almost a third of the residues. Collagen is the main supportive protein of skin, tendons, bones, and connective tissue and promotes their health and healing. (NCI04)

L-proline is pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles. (Source: ChEBI)

Basic information
Product Name: L-Proline
Synonyms: L-Proline; L-2-Pyrrolidinecarboxylic acid; L-PROLINE, NATURAL; L-PROLINE, SYNTHETIC;L-(-)-PROLINE ((S)-(-)-PROLINE); L-PROLINE  99%; Prolinum; Prolina; (S)-Pyrrolidine-2-carboxylic acid
CAS: 147-85-3
MW: 115.13
EINECS: 205-702-2
Product Categories: Amino Acids;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Food & Feed ADDITIVES;
Chemical Structure


Chemical Properties  
Melting point  228 °C (dec.) (lit.)
alpha  -85.5 º (c=4, H2O)
Boiling point  215.41°C (rough estimate)
density  1.35
refractive index  -85 ° (C=4, H2O)
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
pka 1.95, 10.64(at 25℃)
form  powder
color  White
PH 6.0-7.0 (25℃, 1M in H2O)
optical activity [α]20/D 85.0±1.0°, c = 5% in H2O
Water Solubility  soluble
λmax λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
Sensitive  Hygroscopic
JECFA Number 1425
Merck  14,7780
BRN  80810
Stability: Stable. Incompatible with strong oxidizing agents.
Usage And Synthesis
Chemical Properties White crystalline powder
L-Proline, an amino acid, is odorless or has a slight, characteristic odor with a slightly sweet taste.
Occurrence Reported found as a component in many proteins; also widely occurring as the free acid in natural products. A major constituent of collagen, the main fibrous protein found in bone, cartilage and other connective tissue.
Uses amino acid, nutrient

Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

MSDS: MSDS available.

COA: COA can be available if you send us inquiry.

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