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RIFAMYCIN SV
- Chemical Name:RIFAMYCIN SV
- CAS No.:6998-60-3
- MF: C37H47NO12
- MW:697.77
- Specification: USP|EP|BP
- Purity:98%,99% or As customer requested
- Solubility：Soluble in MeOH, EtOH, Me2CO and EtOAc
- Product Categories: Intermediates & Fine Chemicals; Antibiotics; Pharmaceuticals; APIs
- Test method: HPLC
Description
RIFAMYCIN SV is a natural antibiotic produced by Streptomyces mediterranei, Rifamycin (Ansamycin Family) is a commonly used antimycobacterial drug that inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis; it blocks RNA-polymerase transcription initiation.
RIFAMYCIN SV has an activity spectrum against Gram-positive and Gram-negative bacteria, but is mainly used against Mycobacterium sp. (especially M. tuberculosis) in association with other agents to overcome resistance.
Rifamycin is also a nonabsorbable RIFAMYCIN SV-like antibacterial agent that is used as treatment of travelers’ diarrhea. Rifamycin has minimal oral absorption and has not been implicated in causing liver test abnormalities or clinically apparent liver injury.
RIFAMYCIN SVBasic information
| Product Name: | RIFAMYCIN SV |
| Synonyms: | RIFAMYCIN SV; 17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-21-acetate;rifamicinesv; rifocin; rifocyn; Rifamycin S-Na; Rifaximin EP Impurity C; |
| CAS: | 6998-60-3 |
| MF: | C37H47NO12 |
| MW: | 697.77 |
| EINECS: | 230-273-3 |
| Product Categories: | Intermediates & Fine Chemicals; Antibiotics; Pharmaceuticals; APIs |
RIFAMYCIN SV Chemical Structure
Rifocin Chemical Properties
| Melting point | 300° (dec 140°) |
| alpha | D20 -4° (methanol) |
| Boiling point | 701.9°C (rough estimate) |
| density | 1.2275 (rough estimate) |
| refractive index | 1.5350 (estimate) |
| pka | 5.17±0.70(Predicted) |
Rifocin Usage And Synthesis
How about the Pharmaceutical Applications of rifamycin？
The simplest rifamycin in clinical use, obtained by elimination of a glycolic moiety from rifamycin B. Formulated as sodium salt for parenteral administration. Also available for topical use. Its activity, general properties and pharmacokinetics are very similar to those of rifamide. It is orally absorbed and excreted mainly in the bile. Intramuscular doses of 250 mg produce mean plasma levels of about 2 mg/L. The plasma half-life is around 2 h.
In addition to uses similar to those of rifamide, it is administered topically in surgery and has been proposed for the treatment of synovitis by intra-articular injections. A topical preparation is used for application to wounds and bedsores. Cases of anaphylactic reactions have been reported after local administration of the drug.
MSDS: MSDS available.
COA: COA can be available if you send us inquiry.
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