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RIFAMYCIN SV (6998-60-3) C37H47NO12

  • Chemical Name:RIFAMYCIN SV
  • CAS No.:6998-60-3
  • MF: C37H47NO12
  • MW:697.77
  • Specification: USP|EP|BP
  • Purity:98%,99% or As customer requested
  • Solubility:Soluble in MeOH, EtOH, Me2CO and EtOAc
  • Product Categories: Intermediates & Fine Chemicals; Antibiotics; Pharmaceuticals; APIs
  • Test method: HPLC
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Rifamycin is a natural antibiotic produced by Streptomyces mediterranei, Rifamycin (Ansamycin Family) is a commonly used antimycobacterial drug that inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis; it blocks RNA-polymerase transcription initiation. Rifamycin has an activity spectrum against Gram-positive and Gram-negative bacteria, but is mainly used against Mycobacterium sp. (especially M. tuberculosis) in association with other agents to overcome resistance. (Source: NCI Thesaurus (NCIt))

Rifamycin is also a nonabsorbable rifampin-like antibacterial agent that is used as treatment of travelers’ diarrhea. Rifamycin has minimal oral absorption and has not been implicated in causing liver test abnormalities or clinically apparent liver injury. (Source: LiverTox)

RIFAMYCIN SVBasic information   
Product Name: RIFAMYCIN SV
Synonyms: RIFAMYCIN SV; 17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-21-acetate;rifamicinesv; rifocin; rifocyn; Rifamycin S-Na; Rifaximin EP Impurity C;
CAS: 6998-60-3
MF: C37H47NO12
MW: 697.77
EINECS: 230-273-3
Product Categories:

Intermediates & Fine Chemicals; Antibiotics; Pharmaceuticals; APIs

RIFAMYCIN SV Chemical Structure

RIFAMYCIN SV            

Rifocin Chemical Properties    
Melting point  300° (dec 140°)
alpha  D20 -4° (methanol)
Boiling point  701.9°C (rough estimate)
density  1.2275 (rough estimate)
refractive index  1.5350 (estimate)
pka 5.17±0.70(Predicted)

Rifocin Usage And Synthesis


How about the Pharmaceutical Applications of rifamycin?

The simplest rifamycin in clinical use, obtained by elimination of a glycolic moiety from rifamycin B. Formulated as sodium salt for parenteral administration. Also available for topical use. Its activity, general properties and pharmacokinetics are very similar to those of rifamide. It is orally absorbed and excreted mainly in the bile. Intramuscular doses of 250 mg produce mean plasma levels of about 2 mg/L. The plasma half-life is around 2 h.
In addition to uses similar to those of rifamide, it is administered topically in surgery and has been proposed for the treatment of synovitis by intra-articular injections. A topical preparation is used for application to wounds and bedsores. Cases of anaphylactic reactions have been reported after local administration of the drug.    


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