What is nimesulide

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with pain medication and fever reducing properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis, and primary dysmenorrhoea in adolescents and adults above 12 years old.

Side effects may include liver problems. It has a multifactorial mode of action and is characterized by a fast onset of action. It works by blocking the production of prostaglandins (a chemical associated with pain), thereby relieving pain and inflammation.

Nimesulide is not available in the United States, however is used in other countries for acute pain.[1] It may be used for pain, including period pains. Nimesulide is not recommended long-term, as for chronic conditions such as arthritis. This is due to its association with an increased risk of liver toxicity, including liver failure. Despite its risk of hepatotoxicity, a 2012 evaluation by the European Medicines Agency (EMA) concluded that the overall benefit/risk profile of nimesulide is favourable and in line with that of the other NSAIDs such as diclofenac, ibuprofen, and naproxen provided that the duration of use is limited to 15 days and the dose does not exceed 200 mg/day.

What is nimesulide tablet?

NIMESULIDE belongs to a class of painkillers called as non-steroidal anti-inflammatory drugs (NSAIDs). Nimesulide is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain.

Pain can be temporary (acute) or long-lasting (chronic) in nature. Acute pain is caused by damage to the tissues of the muscle, bone, or other organs for a short time. While, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc.

NIMESULIDE is composed of Nimesulide, which helps to treat symptoms of arthritis and dysmenorrhea (painful periods or menstrual cramps). Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction, or injury. It works by blocking the effect of a chemical known as prostaglandin (PGs) responsible for inducing pain and inflammation in our body.

NIMESULIDE can be taken with or after the meal. If stomach upset or irritation occurs, it is advisable to take NIMESULIDE with food or milk. It should be swallowed whole with a glass of water. Do not crush or chew the tablets. Do not take NIMESULIDE if your pain lasts for more than ten days or fever lasting for more than three days. Do not take a double dose if you missed one dose. Like all medicines, NIMESULIDE may cause common side effects like nausea, diarrhoea, changes in liver function tests, vomiting, and rash. Although not everybody gets them. Stop taking this medicine if you experience severe allergic reactions like chest tightness, breathing difficulties, fever, skin rashes, or increased heart rate.

Do not take NIMESULIDE if you are allergic to NIMESULIDE, and other painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children, people with liver disease, heart disease, and gastric ulcers/bleeding problems. NIMESULIDE affects fertility and can pass in milk so the use of NIMESULIDE should be avoided in pregnant and nursing mothers. NIMESULIDE may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid alcohol consumption with NIMESULIDE as it may damage your liver and cause increased side effects on taking this drug.

Consult your doctor if your pain, inflammation, and fever symptoms do not disappear even after ten days. There can be increased chance of problems with joints and tissues around joints in children under 18 years. So let your doctor know if your children have any joint problems during or after treatment with NIMESULIDE. You get severe sunburn or blisters on your skin as an intake of NIMESULIDE may increase the sensitivity of the skin. NIMESULIDE should not be taken with dairy products (like milk or yogurt) or calcium-fortified juices.

What is nimesulide tablet used for?

Nimesulide is a medication used for pain relief and for the prevention of fever. Acute pain, pain due to menstrual cramps, backache, post-operative pain, osteoarthritis and fever are frequently prescribed. This drug belongs to the NSAID class (Non-steroidal anti-inflammatory drug). Nimesulide is an inhibitor of cyclooxygenase, so it eliminates these symptoms efficiently. This medicine targets all components, such as free radicals, proteolytic enzymes, histamine, cyclooxygenases and prostaglandin that lead to the development of swelling.

Is nimesulide dangerous?

Nimesulide should be removed overall because of genuine liver harm

Nimesulide opens patients to deadly liver harm. At the point when a non-steroidal mitigating drug is required, it is smarter to utilize one with a good advantage hurt equilibrium like ibuprofen. EU specialists neglect to safeguard customers.

The International Society of Drug Bulletins (ISDB) considers it unsatisfactory that nimesulide has been permitted to stay on European and a few different business sectors on the planet. This non-steroidal mitigating drug (NSAID) offers no restorative benefit or better gastrointestinal security contrasted and different NSAIDs, while it opens patients to a higher gamble of deadly hepatic problems.

Nimesulide has never been supported for use in nations like USA, UK, Canada, Australia New Zealand, Japan and different nations considering worries over its security profile.

In 2002, Finland and Spain pulled out nimesulide from the market following reports of genuine liver harm. Cases including 2 passings had likewise been accounted for in France at that point. Ireland and Singapore chose to pull out nimesulide from the market in 2007.

The European Medicines Agency has affirmed the hepatic dangers related with nimesulide in 2007, however simply restricted the span of treatment, allowing patients to stay uncovered to a baseless lethal gamble. These weak measures are on the whole the more unsuitable since various other accessible NSAIDs are similarly as compelling and less hazardous.

How did a greater part of EU part states’ rapporteurs who re-evaluated nimesulide presume that the item ought to stay available? For what reason is there such irregularity among EU part states?

The Committee for Medicinal Products for Human Use (CHMP) surveyed the damage brought about by nimesulide in absolute mystery and it is very unsatisfactory for the EU wellbeing specialists to choose to restrict just the span of purpose without introducing the reasoning behind this choice.

If you need to buy nimesulide powder, contact us at email:info@maxmedchem.com.